PDF(Pubmed)
Abstract：
Neural crest (NC) cells are a migratory stem cell population in vertebrate embryogenesis that can give rise to multiple cell types, including osteoblasts, chondrocytes, smooth muscle cells, neurons, glia, and melanocytes, greatly contributing to the development of different tissues and organs. Defects in NC development are implicated in many human diseases, such as numerous syndromes, craniofacial aberration and congenital heart defects. Research on NC development has gained intense interest and made significant progress. Recent studies showed that the Hippo-Yap pathway, a conserved fundamental pathway with key roles in regulation of cell proliferation, survival, and differentiation, is indispensable for normal NC development. However, the roles and mechanisms of the Hippo-Yap pathway in NC development remain largely unknown. In this review, we summarize the key functions of the Hippo-Yap pathway indicated in NC induction, migration, proliferation, survival, and differentiation, as well as the diseases caused by its dysfunction in NC cells. We also discuss emerging current and future studies in the investigation of the Hippo-Yap pathway in NC development.
摘要：
神经c（NC）细胞是脊椎动物胚胎发育中的迁移干细胞群体，可以产生多种细胞类型，包括成骨细胞,软骨细胞,平滑肌细胞，神经元，glia,和黑素细胞，极大地促进了不同组织和器官的发育。数控发育的缺陷与许多人类疾病有关，例如许多综合征，颅面畸形和先天性心脏缺陷。数控发展的研究引起了人们的强烈兴趣，并取得了重大进展。最近的研究表明，Hippo-Yap途径，在调节细胞增殖中起关键作用的保守的基本途径，生存,和差异化，是数控正常发展不可缺少的。然而,Hippo-Yap通路在NC发育中的作用和机制尚不清楚。在这次审查中,我们总结了Hippo-Yap途径在NC诱导中的关键功能，迁移,扩散,生存,和差异化，以及由其在NC细胞中的功能障碍引起的疾病。我们还讨论了在NC发育中Hippo-Yap途径研究中正在出现的当前和未来研究。
