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Abstract：
OBJECTIVE: This study aimed to explore the therapeutic effect of surgery using platelet-rich plasma combined with a skin flap transplant on open foot fractures with a soft tissue defect.
METHODS: From February 2017 to March 2020, 72 patients with open foot fractures and soft tissue defects were recruited as the study cohort. The patients who underwent surgery with just a flap transplant were placed in the control group (the CG) (35 cases), and the patients who underwent surgery using platelet-rich plasma combined with a flap transplant were placed in the research group (the RG) (37 cases). The wound volume changes before and after the treatment, the wound healing times, the fracture healing times, and any adverse prognostic reactions were observed. The pre- and post-treatment VAS and SF-36 scores were observed and recorded.
RESULTS: The total effective rate in the RG (100.00%) was significantly higher than the total effective rate in the CG (88.57%) (P=0.034). After the treatment, the wound volumes were lower in both groups, and the volume in the RG was smaller than it was in the CG at 3 weeks and 6 weeks after the treatment (P < 0.05). The average wound healing time in the RG (22.40 ± 2.10 days) was significantly lower than it was in the CG (32.20 ± 3.30 days) (P > 0.05). The average fracture healing time in the RG (6.50 ± 2.20 months) was significantly lower than it was in the RG (7.51 ± 2.33 months) (P > 0.05). The total incidence of adverse reactions to the treatment in the RG was 2.70%, and in the CG it was 11.43%. After the treatment, the VAS scores in the RG were significantly lower than they were in the CG (P < 0.05), and the SF-36 scores in the RG were significantly higher than the SF-36 scores in the CG (P < 0.05).
CONCLUSIONS: Platelet-rich plasma combined with a skin flap transplant can accelerate the healing times of wounds and fractures and lessen the occurrence of adverse reactions during the patients\' treatment.
METHODS: From February 2017 to March 2020, 72 patients with open foot fractures and soft tissue defects were recruited as the study cohort. The patients who underwent surgery with just a flap transplant were placed in the control group (the CG) (35 cases), and the patients who underwent surgery using platelet-rich plasma combined with a flap transplant were placed in the research group (the RG) (37 cases). The wound volume changes before and after the treatment, the wound healing times, the fracture healing times, and any adverse prognostic reactions were observed. The pre- and post-treatment VAS and SF-36 scores were observed and recorded.
RESULTS: The total effective rate in the RG (100.00%) was significantly higher than the total effective rate in the CG (88.57%) (P=0.034). After the treatment, the wound volumes were lower in both groups, and the volume in the RG was smaller than it was in the CG at 3 weeks and 6 weeks after the treatment (P < 0.05). The average wound healing time in the RG (22.40 ± 2.10 days) was significantly lower than it was in the CG (32.20 ± 3.30 days) (P > 0.05). The average fracture healing time in the RG (6.50 ± 2.20 months) was significantly lower than it was in the RG (7.51 ± 2.33 months) (P > 0.05). The total incidence of adverse reactions to the treatment in the RG was 2.70%, and in the CG it was 11.43%. After the treatment, the VAS scores in the RG were significantly lower than they were in the CG (P < 0.05), and the SF-36 scores in the RG were significantly higher than the SF-36 scores in the CG (P < 0.05).
CONCLUSIONS: Platelet-rich plasma combined with a skin flap transplant can accelerate the healing times of wounds and fractures and lessen the occurrence of adverse reactions during the patients\' treatment.
摘要：
目的：本研究旨在探讨富血小板血浆联合皮瓣移植治疗足开放性骨折伴软组织缺损的疗效。
方法：从2017年2月至2020年3月，纳入72例开放性足骨折和软组织缺损患者作为研究队列。只需进行皮瓣移植的患者被置于对照组（CG）（35例），将使用富血小板血浆联合皮瓣移植的手术患者置于研究组（RG）中（37例）。治疗前后伤口体积的变化,伤口愈合时间，骨折愈合时间，并观察到任何不良预后反应。观察并记录治疗前后VAS和SF-36评分。
结果：RG的总有效率（100.00%）明显高于CG的总有效率（88.57%）（P=0.034）。治疗后,两组的伤口体积较低，治疗后3周和6周，RG中的体积小于CG中的体积（P<0.05）。RG的平均伤口愈合时间（22.40±2.10天）明显低于CG的（32.20±3.30天）（P>0.05）。RG组平均骨折愈合时间(6.50±2.20个月)明显低于RG组(7.51±2.33个月)(P>0.05)。RG治疗的不良反应总发生率为2.70%,在CG中，它是11.43%。治疗后,RG的VAS评分明显低于CG(P<0.05),RG中的SF-36得分明显高于CG中的SF-36得分（P<0.05）。
结论：富血小板血浆联合皮瓣移植可以加快患者治疗过程中创面和骨折的愈合时间，减少不良反应的发生。
方法：从2017年2月至2020年3月，纳入72例开放性足骨折和软组织缺损患者作为研究队列。只需进行皮瓣移植的患者被置于对照组（CG）（35例），将使用富血小板血浆联合皮瓣移植的手术患者置于研究组（RG）中（37例）。治疗前后伤口体积的变化,伤口愈合时间，骨折愈合时间，并观察到任何不良预后反应。观察并记录治疗前后VAS和SF-36评分。
结果：RG的总有效率（100.00%）明显高于CG的总有效率（88.57%）（P=0.034）。治疗后,两组的伤口体积较低，治疗后3周和6周，RG中的体积小于CG中的体积（P<0.05）。RG的平均伤口愈合时间（22.40±2.10天）明显低于CG的（32.20±3.30天）（P>0.05）。RG组平均骨折愈合时间(6.50±2.20个月)明显低于RG组(7.51±2.33个月)(P>0.05)。RG治疗的不良反应总发生率为2.70%,在CG中，它是11.43%。治疗后,RG的VAS评分明显低于CG(P<0.05),RG中的SF-36得分明显高于CG中的SF-36得分（P<0.05）。
结论：富血小板血浆联合皮瓣移植可以加快患者治疗过程中创面和骨折的愈合时间，减少不良反应的发生。
