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Abstract：
Chronic obstructive pulmonary disease (COPD) and asthma are chronic respiratory diseases with high prevalence and mortality that significantly alter the quality of life in affected patients. While the cellular and molecular mechanisms engaged in the development and evolution of these two conditions are different, COPD and asthma share a wide array of symptoms and clinical signs that may impede differential diagnosis. However, the distinct signaling pathways regulating cough and airway hyperresponsiveness employ the interaction of different cells, molecules, and receptors. Transient receptor potential cation channel subfamily V member 1 (TRPV1) plays a major role in cough and airway inflammation. Consequently, its agonist, capsaicin, is of substantial interest in exploring the cellular effects and regulatory pathways that mediate these respiratory conditions. Increasingly more studies emphasize the use of capsaicin for the inhalation cough challenge, yet the involvement of TRPV1 in cough, bronchoconstriction, and the initiation of inflammation has not been entirely revealed. This review outlines a comparative perspective on the effects of capsaicin and its receptor in the pathophysiology of COPD and asthma, underlying the complex entanglement of molecular signals that bridge the alteration of cellular function with the multitude of clinical effects.
摘要：
慢性阻塞性肺疾病（COPD）和哮喘是慢性呼吸系统疾病，患病率和死亡率高，显着改变患者的生活质量。虽然参与这两种条件的发展和进化的细胞和分子机制是不同的，COPD和哮喘共有一系列可能阻碍鉴别诊断的症状和临床体征。然而,不同的信号通路调节咳嗽和气道高反应性利用不同细胞的相互作用，分子，和受体。瞬时受体电位阳离子通道亚家族V成员1(TRPV1)在咳嗽和气道炎症中起主要感化。因此,它的激动剂，辣椒素,在探索介导这些呼吸病症的细胞效应和调节途径方面具有实质的兴趣。越来越多的研究强调使用辣椒素治疗吸入性咳嗽，然而TRPV1参与咳嗽，支气管收缩，炎症的开始尚未完全揭示。这篇综述概述了辣椒素及其受体在COPD和哮喘病理生理学中的作用的比较观点。潜在的复杂纠缠的分子信号，桥梁细胞功能的改变与多种临床效应。
