改性壳聚糖 / 羧甲基壳聚糖 “增强 ” 电荷逆转纳米制剂的体外 / 体内抗肿瘤研究。
关键词: Antitumor nanosystem Charge reversal Chitosan derivatives Polysaccharide-based nanoformulation Self-assembly
Mesh : Animals Antineoplastic Agents / chemistry therapeutic use Apoptosis / drug effects Carbohydrate Sequence Chitosan / analogs & derivatives chemical synthesis chemistry metabolism Dendrimers / chemical synthesis chemistry metabolism Doxorubicin / chemistry therapeutic use Drug Carriers / chemistry metabolism Drug Liberation Endocytosis / physiology Hep G2 Cells Humans Hydrogen-Ion Concentration Lysosomes / metabolism Male Maleic Anhydrides / chemistry metabolism Mice, Inbred BALB C Necrosis / chemically induced Neoplasms / diagnostic imaging drug therapy Polyamines / chemical synthesis chemistry metabolism Xenograft Model Antitumor Assays Mice
来 源:
DOI:10.1016/j.carbpol.2021.118268
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