关键词: CB2 PEA analgesic neuropathy palmitoylathenolamide shingles

Mesh : Aged Amides Ethanolamines Herpes Zoster / complications drug therapy Humans Male Neuralgia / drug therapy etiology pathology Palmitic Acids / therapeutic use Pisum sativum Quality of Life

来  源:   DOI:10.1177/02601060211019669   PDF(Sci-hub)

Abstract:
UNASSIGNED: Neuropathic pain is a condition caused by a lesion or disease of the somatosensory nervous system. It may present as debilitating pain with a sensation of burning and electric-like symptoms and is often difficult to manage effectively. Although pharmacological medications are the first line of treatment, multidisciplinary teams are sometimes required to provide appropriate treatment to improve quality of life and overall wellbeing.
UNASSIGNED: The aim of this study is to present a case of post herpetic neuralgia relieved successfully by the compound palmitoylethanolamide (PEA) - a natural alternative to pharmacological pain relief.
UNASSIGNED: We present the case of a 67 year-old male with ongoing post-herpetic neuralgia, over a 3-year period, as a result of complications from shingles (herpes zoster). Previous studies on the relationship between PEA and neuropathy were reviewed, with an attempt to discuss the possible underlying mechanism of PEA on neuropathic pain.
UNASSIGNED: PEA demonstrated effective pain relief within 48 hours at an administered daily dose of 900 mg (10 mg/kg).
UNASSIGNED: PEA may offer a valid nutraceutical treatment for practitioners.
摘要:
神经性疼痛是由体感神经系统的病变或疾病引起的病症。它可能表现为衰弱性疼痛,伴有灼热和电样症状,通常难以有效管理。虽然药物治疗是一线治疗,有时需要多学科团队提供适当的治疗,以改善生活质量和整体福祉。
本研究的目的是提供一种通过化合物棕榈酰乙醇胺(PEA)成功缓解的带状疱疹后神经痛的病例-一种药物缓解疼痛的天然替代品。
我们介绍了一个67岁的男性,患有持续的带状疱疹后神经痛,在三年的时间里,由于带状疱疹(带状疱疹)的并发症。对PEA与神经病变关系的研究进行了综述,试图探讨PEA对神经性疼痛的可能潜在机制。
PEA在900mg(10mg/kg)的每日给药剂量下在48小时内表现出有效的疼痛缓解。
PEA可以为从业者提供有效的营养治疗。
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