New perspective into mesenchymal stem cells: Molecular mechanisms regulating osteosarcoma.

• 发表时间: Aug 2021
• 来源期刊: J Bone Oncol
• DOI: 10.1016/j.jbo.2021.100372
• PMID: 34258182
• 文章类型: Journal Article
• 作者列表: Chang X,Ma Z,Zhu G,Lu Y,Yang J

关键词: 3TSR, Three type 1 repeats; 5 FC, 5-fluorocytosine; AD-MSCs, Adipose-derived MSCs; AQP1, Aquaporin-1; BMSC-derived exosomes, BMSC-Exos; BMSCs, Bone marrow mesenchymal stem cells; CAFs, Carcinoma-associated-fibroblasts; CRC, Colorectal cancer; CSF, Colony-stimulating factor; Cellular communication; Clinical application; DOX, Doxorubicin; DP-MSCs, Dental pulp-derived MSCs, hUC-MSCs, Human umbilical cord MSCs; ECM, Extracellular matrix; ESCs, embryonic stem cells; EVs, Extracellular vesicles; GBM, Glioblastoma; HCC, hepatocellular carcinoma; LINE-1, Long interspersing element 1; MCP-1, Monocyte chemoattractant protein-1; MSC-Exos, MSC-derived exosomes; MSC-MVs, MSC microvesicles; MSCs; MSCs, Mesenchymal stem cells; OPG, osteoprotegerin; OS, osteosarcoma; Osteosarcoma; PDGFRα, Platelet derived growth factor receptor α; PDGFRβ, Platelet derived growth factor receptor β; PDGFα, Platelet derived growth factor α; S TRAIL, Secretable variant of the TNF-related apoptosis-inducing ligand; SD-MSCs, stressed MSCs; SDF-1, Stromal cell-derived factor 1; TGF, Transforming growth factor; TME; TME, Tumor microenvironment; TNF, Tumor necrosis factor; TRA2B, Transformer 2β; VEGF, Vascular endothelial growth factor; hASCs, human adipose stem cells; iPSCs, induced pluripotent stem cells; yCD::UPRT, Yeast cytosine deaminase::uracil phosphoribosyl transferase

Abstract

Mesenchymal stem cells (MSCs) are multipotent stem cells with significant potential for regenerative medicine. The tumorigenesis of osteosarcoma is an intricate system and MSCs act as an indispensable part of this, interacting with the tumor microenvironment (TME) during the process. MSCs link to cells by acting on each component in the TME via autocrine or paracrine extracellular vesicles for cellular communication. Because of their unique characteristics, MSCs can be modified and processed into good biological carriers, loaded with drugs, and transfected with anticancer genes for the targeted treatment of osteosarcoma. Previous high-quality reviews have described the biological characteristics of MSCs; this review will discuss the effects of MSCs on the components of the TME and cellular communication and the prospects for clinical applications of MSCs.