PDF(Pubmed)
Abstract：
Objectives: Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI) are common in elderly population, and constitute a high-risk group for progression to dementia. Innovative, complex, and engaging non-pharmacological methods of cognitive stimulation, implementable at this stage, are needed. The aim of the study was to determine the effect of Computerized Cognitive Training (CCT) combined with Whole Body Stimulation (WBC) on cognitive functions of older adults with SCD and MCI. Methods: A 9-week single-blind pre/post case control trial was conducted. The study enrolled 84 adults aged 60 or older, allocated to one of two intervention groups: EG; CCT with psychoeducation, EG2; CCT with psychoeducation and 10 WBC sessions, or the control group (CG), which comprised patients receiving usual care. The primary outcome measures were cognitive functions evaluated with MoCA scale and several other neuropsychological tools. Depressive symptoms assessed with the GDS scale constituted the secondary outcome measures. Results: The results show evidence for increased performance in the assessment of general cognitive functioning in both EGs (p ≤ 0.05). Significant improvement was also visible in several cognitive domains, such as verbal fluency (EG1 & EG2), learning ability and immediate memory (EG1 & EG2), delayed memory (EG2), attentional control (EG1), and information processing (EG2) (p ≤ 0.05). However, only in the group with combined interventions (CCT + WBC) the participants presented significantly less depressive symptoms (p ≤ 0.05). Conclusions: The results of the study suggest that CCT, especially in combination with WBC, might be a practical and effective method of improving cognitive performance. Moreover, this combination leads to a reduction of depressive symptoms.
摘要：
目的:主观认知衰退(SCD)和轻度认知损害(MCI)在老年人群中普遍存在,并构成进展为痴呆的高危人群。创新,复杂，从事认知刺激的非药理学方法，在这个阶段是可以实施的，是需要的。该研究的目的是确定计算机认知训练（CCT）结合全身刺激（WBC）对SCD和MCI老年人认知功能的影响。方法：进行为期9周的单盲病例前/后对照试验。该研究招募了84名60岁或以上的成年人，分配给两个干预组之一：EG；CCT与心理教育，EG2；CCT与心理教育和10次WBC会议，或对照组（CG），其中包括接受常规护理的患者。主要结果指标是使用MoCA量表和其他几种神经心理学工具评估的认知功能。用GDS量表评估的抑郁症状构成次要结局指标。结果：结果显示，在两个EGs的一般认知功能评估中，有证据表明表现增强（p≤0.05）。在几个认知领域也有显著的改善，如口语流利（EG1和EG2），学习能力和即时记忆(EG1和EG2)，延迟记忆（EG2），注意控制（EG1），和信息处理(EG2)(p≤0.05)。然而,仅在联合干预(CCT+WBC)组中,参与者的抑郁症状显著减少(p≤0.05).结论：研究结果表明，CCT，尤其是与WBC结合，可能是提高认知能力的一种实用有效的方法。此外，这种组合导致抑郁症状的减少。
