PDF(Pubmed)
Abstract：
Biophysical properties of the extracellular environment dynamically regulate cellular fates. In this review, we highlight silk, an indispensable polymeric biomaterial, owing to its unique mechanical properties, bioactive component sequestration, degradability, well-defined architectures, and biocompatibility that can regulate temporospatial biochemical and biophysical responses. We explore how the materiobiology of silks, both mulberry and non-mulberry based, affect cell behaviors including cell adhesion, cell proliferation, cell migration, and cell differentiation. Keeping in mind the novel biophysical properties of silk in film, fiber, or sponge forms, coupled with facile chemical decoration, and its ability to match functional requirements for specific tissues, we survey the influence of composition, mechanical properties, topography, and 3D geometry in unlocking the body\'s inherent regenerative potential.
摘要：
细胞外环境的生物物理性质动态调节细胞命运。在这次审查中,我们强调丝绸，一种不可或缺的高分子生物材料，由于其独特的机械性能，生物活性成分螯合，降解性，定义良好的架构，和生物相容性，可以调节时空生化和生物物理反应。我们探索丝绸的材料生物学，桑树和非桑树，影响细胞行为，包括细胞粘附，细胞增殖，细胞迁移，和细胞分化。牢记丝绸在电影中的新颖生物物理特性，纤维,或海绵形式，加上简易的化学装饰，以及它满足特定组织功能要求的能力，我们调查了构图的影响，机械性能，地形,和3D几何在解锁身体的固有再生潜力。
