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Abstract：
Platelet-rich plasma (PRP) has long been used for the restoration of hair in conjunction with microneedling or on its own. Fat grafting to the scalp has also been utilized in the past to improve the quality of hair and the possibility of successful hair transplant. The novel therapy reported in this case series combines the natural progression of these two techniques and utilizes synergistic effects to improve the quality of hair, either in preparation for micrografting or without hair transplant.
To demonstrate the principles behind the novel approach to restoration of hair and the rationale for its use.
A review of the evidence for PRP and fat transfer for non-scarring alopecia serves as the foundation for the combination treatment reported herein. Through presentation of three cases in this series, we provide examples of the utility of this approach for non-scarring alopecia. This report includes a female who suffered non-scarring alopecia following COVID-19 hospitalization and intensive care stay where she lost a large percentage of her hair, in addition to two male patients suffering from androgenic alopecia.
Platelet-rich plasma-hybridized adipose transplant hair was shown in these three cases to improve both the quality and density of hair. It improved the density of hair in all patients and was characterized first by a short period of transient hair loss followed by new hair growth which develops starting at 4 weeks and was readily apparent at 12-week follow-up. Results were maintained at 6-month and 1-year follow-up.
PHAT hair offers a combination of beneficial effects-namely the unique healing properties and growth signaling provided by PRP, along with adipocyte angiogenic and growth signaling, which both work to improve scalp quality. The combination of these effects is better than previously characterized PRP injections alone in the hands of these individual practices. This may be due to synergistic interactions at a cellular level, but additional clinical studies are needed to better understand this novel treatment and the observed effects.
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
To demonstrate the principles behind the novel approach to restoration of hair and the rationale for its use.
A review of the evidence for PRP and fat transfer for non-scarring alopecia serves as the foundation for the combination treatment reported herein. Through presentation of three cases in this series, we provide examples of the utility of this approach for non-scarring alopecia. This report includes a female who suffered non-scarring alopecia following COVID-19 hospitalization and intensive care stay where she lost a large percentage of her hair, in addition to two male patients suffering from androgenic alopecia.
Platelet-rich plasma-hybridized adipose transplant hair was shown in these three cases to improve both the quality and density of hair. It improved the density of hair in all patients and was characterized first by a short period of transient hair loss followed by new hair growth which develops starting at 4 weeks and was readily apparent at 12-week follow-up. Results were maintained at 6-month and 1-year follow-up.
PHAT hair offers a combination of beneficial effects-namely the unique healing properties and growth signaling provided by PRP, along with adipocyte angiogenic and growth signaling, which both work to improve scalp quality. The combination of these effects is better than previously characterized PRP injections alone in the hands of these individual practices. This may be due to synergistic interactions at a cellular level, but additional clinical studies are needed to better understand this novel treatment and the observed effects.
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
摘要：
富含血小板的血浆（PRP）长期以来一直与微针结合或单独用于修复头发。过去还利用头皮上的脂肪移植来改善头发的质量和成功的头发移植的可能性。本病例系列报道的新疗法结合了这两种技术的自然进展，并利用协同作用来改善头发的质量，无论是在准备微移植或没有头发移植。
展示头发修复新方法背后的原理及其使用原理。
对PRP和脂肪转移用于非瘢痕性脱发的证据的综述作为本文报道的联合治疗的基础。通过介绍本系列中的三个案例，我们提供了这种方法对非瘢痕性脱发的实用性的例子。这份报告包括一名女性，她在COVID-19住院和重症监护住院后出现了非疤痕性脱发，她失去了很大比例的头发，除了两名男性患者患有雄激素性脱发。
在这三种情况下，富含血小板的血浆杂交的脂肪移植头发可以改善头发的质量和密度。它改善了所有患者的头发密度，首先是短暂的短暂性脱发，然后是新的头发生长，从4周开始发展，并在12周的随访中很明显。结果维持在6个月和1年随访。
PHAT头发提供了有益效果的组合-即PRP提供的独特的愈合特性和生长信号，随着脂肪细胞血管生成和生长信号，两者都能提高头皮质量。在这些个体实践中,这些效果的组合比先前单独表征的PRP注射更好。这可能是由于细胞水平的协同相互作用，但是需要更多的临床研究来更好地了解这种新的治疗方法和观察到的效果。
本期刊要求作者为每篇文章分配一定程度的证据。对于这些循证医学评级的完整描述，请参阅目录或在线作者说明www。springer.com/00266.
展示头发修复新方法背后的原理及其使用原理。
对PRP和脂肪转移用于非瘢痕性脱发的证据的综述作为本文报道的联合治疗的基础。通过介绍本系列中的三个案例，我们提供了这种方法对非瘢痕性脱发的实用性的例子。这份报告包括一名女性，她在COVID-19住院和重症监护住院后出现了非疤痕性脱发，她失去了很大比例的头发，除了两名男性患者患有雄激素性脱发。
在这三种情况下，富含血小板的血浆杂交的脂肪移植头发可以改善头发的质量和密度。它改善了所有患者的头发密度，首先是短暂的短暂性脱发，然后是新的头发生长，从4周开始发展，并在12周的随访中很明显。结果维持在6个月和1年随访。
PHAT头发提供了有益效果的组合-即PRP提供的独特的愈合特性和生长信号，随着脂肪细胞血管生成和生长信号，两者都能提高头皮质量。在这些个体实践中,这些效果的组合比先前单独表征的PRP注射更好。这可能是由于细胞水平的协同相互作用，但是需要更多的临床研究来更好地了解这种新的治疗方法和观察到的效果。
本期刊要求作者为每篇文章分配一定程度的证据。对于这些循证医学评级的完整描述，请参阅目录或在线作者说明www。springer.com/00266.
