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Abstract：
BACKGROUND: Palmoplantar hyperkeratosis is a cutaneous manifestation that had not been clearly associated with infection by the human T-cell lymphotropic virus, which is a retrovirus that in most cases does not develop clinical pathologies and its symptoms may be undetected. The skin is one of the most affected organs, however until now only seborrheic dermatitis, xerosis/ichthyosis and infective dermatitis associated with HTLV-1 have been described as cutaneous clinical manifestations of this disease.
METHODS: We present the case of a 36-year-old male patient with serologically documented HTLV-1 infection, who presented symptoms of diarrhea, malabsorption due to Strongyloides stercoralis, and in whom a physical examination revealed an association with generalized xerosis and palmoplantar keratoderma confirmed by skin biopsy. Other infectious etiologies and malignancy were ruled out. This clinical manifestation was managed with dermal hydration, and skin care which improved the thickened skin and make it less noticeable.
CONCLUSIONS: According to our experience, this is the first reported case of palmoplantar keratoderma associated with a human lymphotropic virus infection. This is a skin manifestation that has not been confirmed in conjunction with HTLV-I before. This implies that palmoplantar keratoderma is a new clinical manifestation of this infection, that should be considered in the initial approach of patients in endemic areas with these dermatological characteristics.
METHODS: We present the case of a 36-year-old male patient with serologically documented HTLV-1 infection, who presented symptoms of diarrhea, malabsorption due to Strongyloides stercoralis, and in whom a physical examination revealed an association with generalized xerosis and palmoplantar keratoderma confirmed by skin biopsy. Other infectious etiologies and malignancy were ruled out. This clinical manifestation was managed with dermal hydration, and skin care which improved the thickened skin and make it less noticeable.
CONCLUSIONS: According to our experience, this is the first reported case of palmoplantar keratoderma associated with a human lymphotropic virus infection. This is a skin manifestation that has not been confirmed in conjunction with HTLV-I before. This implies that palmoplantar keratoderma is a new clinical manifestation of this infection, that should be considered in the initial approach of patients in endemic areas with these dermatological characteristics.
摘要：
背景：掌plant角化过度是一种皮肤表现，与人类T细胞淋巴细胞病毒感染没有明显联系，这是一种逆转录病毒，在大多数情况下不会发展为临床病理，其症状可能未被发现。皮肤是受影响最大的器官之一,然而直到现在只有脂溢性皮炎，与HTLV-1相关的干燥病/鱼鳞病和感染性皮炎已被描述为该疾病的皮肤临床表现。
方法：我们介绍了一名36岁的男性患者，其血清学记录为HTLV-1感染，出现腹泻症状的人，由于类圆圆线虫的吸收不良，体格检查显示与皮肤活检证实的广泛性干燥和掌plant角化病有关。排除了其他感染性病因和恶性肿瘤。这种临床表现通过皮肤水化来管理，和皮肤护理，改善了增厚的皮肤，使其不那么明显。
结论：根据我们的经验，这是首例报道的与人类淋巴细胞病毒感染相关的掌plant角化病。这是之前尚未与HTLV-I结合确认的皮肤表现。这意味着掌plant角化症是这种感染的新临床表现，在具有这些皮肤病学特征的流行地区的患者的初始方法中应考虑这一点。
方法：我们介绍了一名36岁的男性患者，其血清学记录为HTLV-1感染，出现腹泻症状的人，由于类圆圆线虫的吸收不良，体格检查显示与皮肤活检证实的广泛性干燥和掌plant角化病有关。排除了其他感染性病因和恶性肿瘤。这种临床表现通过皮肤水化来管理，和皮肤护理，改善了增厚的皮肤，使其不那么明显。
结论：根据我们的经验，这是首例报道的与人类淋巴细胞病毒感染相关的掌plant角化病。这是之前尚未与HTLV-I结合确认的皮肤表现。这意味着掌plant角化症是这种感染的新临床表现，在具有这些皮肤病学特征的流行地区的患者的初始方法中应考虑这一点。
