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Abstract：
Risk-reducing surgeries decrease the risk of developing breast cancer by 95%. But this type of surgery can be life-changing. This systematic review analyzed anxiety/depressive symptomatology, body image and quality of life on BRCA1/2 mutation carriers with or without a previous oncological history who have undergone risk-reducing mastectomy. PRISMA method was used to conduct this review. The initial search identified 234 studies. However, only 7 achieved the inclusion criteria. No statistically significant differences were found in terms of anxious symptomatology. One study found that depressive symptomatology had increased significantly in women without previous oncological history at the long-term follow-up measure. Women who underwent bilateral risk-reducing mastectomy and implant-based breast reconstruction tended to be satisfied with their body image/cosmetic outcome. No differences were reported at long-term follow-ups, independently of the surgery performed.
摘要：
降低风险的手术可将患乳腺癌的风险降低95％。但是这种手术可以改变生活。这项系统评价分析了焦虑/抑郁症状，有或没有既往肿瘤病史的BRCA1/2突变携带者接受过降低风险的乳房切除术的身体形象和生活质量。本综述采用PRISMA方法进行。最初的搜索确定了234项研究。然而,只有7人达到了纳入标准。在焦虑症状方面没有发现统计学上的显着差异。一项研究发现，在长期随访措施中，没有肿瘤病史的女性的抑郁症状明显增加。接受双侧降低风险的乳房切除术和基于植入物的乳房重建的女性倾向于对其身体形象/美容结果感到满意。在长期随访中没有报告差异，独立于手术。
