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Abstract：
Early allograft dysfunction (EAD) is a postoperative complication that may cause graft failure and mortality after liver transplantation. The objective of this study was to examine whether the preoperative serum uric acid (SUA) level may predict EAD. We performed a prospective observational study, including 61 donor/recipient pairs who underwent living donor liver transplantation (LDLT). In the univariate and multivariate analysis, SUA ≤4.4 mg/dL was related to a five-fold (odds ratio (OR): 5.16, 95% confidence interval (CI): 1.41-18.83; OR: 5.39, 95% CI: 1.29-22.49, respectively) increased risk for EAD. A lower preoperative SUA was related to a higher incidence of and risk for EAD. Our study provides a new predictor for evaluating EAD and may exert a protective effect against EAD development.
摘要：
早期同种异体移植功能障碍（EAD）是肝移植术后可能导致移植失败和死亡的术后并发症。这项研究的目的是检查术前血清尿酸（SUA）水平是否可以预测EAD。我们进行了一项前瞻性观察研究，包括61对接受活体肝移植（LDLT）的供体/受体。在单变量和多变量分析中，SUA≤4.4mg/dL与EAD风险增加5倍（比值比（OR）：5.16，95％置信区间（CI）：1.41-18.83；OR：5.39，95％CI：1.29-22.49）相关。术前SUA较低与EAD的发生率和风险较高有关。我们的研究为评估EAD提供了新的预测指标，并可能对EAD的发展产生保护作用。
