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Abstract：
Experimental burn models are essential tools for simulating human burn injuries and exploring the consequences of burns or new treatment strategies. Unlike clinical studies, experimental models allow a direct comparison of different aspects of burns under controlled conditions and thereby provide relevant information on the molecular mechanisms of tissue damage and wound healing, as well as potential therapeutic targets. While most comparative burn studies are performed in animal models, a few human or humanized models have been successfully employed to study local events at the injury site. However, the consensus between animal and human studies regarding the cellular and molecular nature of systemic inflammatory response syndrome (SIRS), scarring, and neovascularization is limited. The many interspecies differences prohibit the outcomes of animal model studies from being fully translated into the human system. Thus, the development of more targeted, individualized treatments for burn injuries remains a major challenge in this field. This review focuses on the latest progress in experimental burn models achieved since 2016, and summarizes the outcomes regarding potential methodological improvements, assessments of molecular responses to injury, and therapeutic advances.
摘要：
实验性烧伤模型是模拟人体烧伤和探索烧伤后果或新治疗策略的重要工具。与临床研究不同,实验模型允许在受控条件下直接比较烧伤的不同方面，从而提供有关组织损伤和伤口愈合的分子机制的相关信息。以及潜在的治疗目标。虽然大多数比较烧伤研究是在动物模型中进行的，一些人类或人性化模型已成功用于研究受伤部位的局部事件.然而,关于全身炎症反应综合征（SIRS）的细胞和分子性质的动物和人类研究之间的共识，疤痕,新血管形成是有限的。许多种间差异阻止了动物模型研究的结果完全转化为人类系统。因此，更有针对性的发展,烧伤的个体化治疗仍是该领域的一大挑战.这篇综述集中于自2016年以来在实验性烧伤模型方面取得的最新进展，并总结了有关潜在方法学改进的结果。对损伤的分子反应评估，和治疗进展。
