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Abstract：
The current understanding of deviations of human microbiota caused by antibiotic treatment is poor. In an attempt to improve it, a proof-of-principle spectroscopic study of the breath of one volunteer affected by a course of antibiotics for Helicobacter pylori eradication was performed. Fourier transform spectroscopy enabled searching for the absorption spectral structures sensitive to the treatment in the entire mid-infrared region. Two spectral ranges were found where the corresponding structures strongly correlated with the beginning and end of the treatment. The structures were identified as methyl ester of butyric acid and ethyl ester of pyruvic acid. Both acids generated by bacteria in the gut are involved in fundamental processes of human metabolism. Being confirmed by other studies, measurement of the methyl butyrate deviation could be a promising way for monitoring acute gastritis and anti-Helicobacter pylori antibiotic treatment.
摘要：
目前对抗生素治疗引起的人类微生物群偏差的认识很差。为了改进它，对一名接受根除幽门螺杆菌的抗生素疗程的志愿者的呼吸进行了原理验证光谱研究.傅里叶变换光谱学能够在整个中红外区域搜索对治疗敏感的吸收光谱结构。发现了两个光谱范围，其中相应的结构与治疗的开始和结束密切相关。结构被鉴定为丁酸甲酯和丙酮酸乙酯。肠道中细菌产生的两种酸都参与人体代谢的基本过程。被其他研究证实，测量丁酸甲酯的偏差可能是监测急性胃炎和抗幽门螺杆菌抗生素治疗的一种有前途的方法。
