UNASSIGNED: A prospective analysis was performed of 254 patients who were admitted with head injury to our hospital, 35 of whom had posttraumatic epilepsy (32 males and 3 females); 30 adults (28 men, 2 women) with a similar demographic profile were selected randomly as control individuals. Blood levels of TNF-α, IL-6, and INF-γ were evaluated in all participants.
UNASSIGNED: IL-6 levels were significantly higher in the PTE group (121.36 pg/mL; standard deviation [SD], 89.23) than in the nonseizure group (65.30 pg/mL; SD, 74.75; P = 0.01), whereas there was no significant difference between the seizure group (11.42 pg/mL; SD, 7.84) and the nonseizure groups (10.58 pg/mL; SD, 7.84) in terms of TNF-α level (P = 0.343). The level of INF-γ in the seizure group tended to be higher (mean, 1.88 pg/mL, SD, 2.13 in seizure group vs. 1.10 pg/mL, SD, 1.45 in the nonseizure group); however, no statistically significant difference was detected among the 2 groups (P = 0.09).
UNASSIGNED: Posttraumatic epilepsy has a strong association with an increased level of IL-6 in the blood. INF-γ may or may not be associated with PTE. However, TNF-α was not associated with PTE.
■对我们医院收治的254例头部受伤患者进行了前瞻性分析,其中35人患有创伤后癫痫(32名男性和3名女性);30名成年人(28名男性,2名具有相似人口统计学特征的妇女)被随机选择为对照个体。血液中TNF-α水平,在所有参与者中评估IL-6和INF-γ。
■PTE组的IL-6水平显着升高(121.36pg/mL;标准偏差[SD],89.23)高于非癫痫组(65.30pg/mL;SD,74.75;P=0.01),而癫痫发作组之间没有显着差异(11.42pg/mL;SD,7.84)和非癫痫发作组(10.58pg/mL;SD,7.84)在TNF-α水平方面(P=0.343)。癫痫发作组的INF-γ水平趋于更高(平均值,1.88pg/mL,SD,2.13在癫痫发作组vs.1.10pg/mL,SD,非癫痫组的1.45);然而,两组间差异无统计学意义(P=0.09)。
■创伤后癫痫与血液中IL-6水平升高密切相关。INF-γ可能与PTE相关或不相关。然而,TNF-α与PTE无关。