PDF(Sci-hub)
Abstract：
OBJECTIVE: Frey\'s syndrome (FS) describes the phenomenon of gustatory sweating and is a cause of significant social embarrassment for sufferers. It has been attributed to aberrant growth of parasympathetic salivatory fibers in the auriculotemporal nerve toward overlying sweat glands. However, the exact mechanism behind this growth is unknown. This review aims to expand and elucidate the theory of aberrant regeneration in FS.
METHODS: A review of the recent literature on nerve regeneration was conducted in order develop further insights into the etiology of both adult onset and pediatric FS.
RESULTS: Neurturin, a neurotrophic factor released by both salivary and sweat glands, was identified as a possible key player in the etiology of FS.
CONCLUSIONS: Further research into the role of neurturin could help to elucidate the pathogenic mechanisms underlying the condition and might reveal neurturin to be a potential target for pharmacological intervention.
METHODS: NA (Basic Science Review).
METHODS: A review of the recent literature on nerve regeneration was conducted in order develop further insights into the etiology of both adult onset and pediatric FS.
RESULTS: Neurturin, a neurotrophic factor released by both salivary and sweat glands, was identified as a possible key player in the etiology of FS.
CONCLUSIONS: Further research into the role of neurturin could help to elucidate the pathogenic mechanisms underlying the condition and might reveal neurturin to be a potential target for pharmacological intervention.
METHODS: NA (Basic Science Review).
摘要：
目的：弗雷综合征（FS）描述了味觉出汗的现象，是患者严重社交尴尬的原因。已将其归因于耳颞部神经中副交感神经唾液纤维向上覆的汗腺的异常生长。然而,这种增长背后的确切机制是未知的。本文旨在扩展和阐明FS中异常再生的理论。
方法：对最近有关神经再生的文献进行了综述，以进一步了解成人发病和儿童FS的病因。
结果：Neurturin，一种由唾液腺和汗腺释放的神经营养因子，被确定为FS病因中可能的关键参与者。
结论：对neurturin作用的进一步研究可能有助于阐明该病的致病机制，并可能揭示neurturin是药物干预的潜在靶点。
方法：NA（基础科学评论）。
方法：对最近有关神经再生的文献进行了综述，以进一步了解成人发病和儿童FS的病因。
结果：Neurturin，一种由唾液腺和汗腺释放的神经营养因子，被确定为FS病因中可能的关键参与者。
结论：对neurturin作用的进一步研究可能有助于阐明该病的致病机制，并可能揭示neurturin是药物干预的潜在靶点。
方法：NA（基础科学评论）。
