Abstract：
Oral cancer (OC) is a common malignant tumor in oral surgery, which is prone to metastasis and the prognosis is not optimistic. Long-non-coding RNA (lncRNA) is a kind of endogenous transcripts with more than 200bp in length, lack of specific and complete open reading frame, and does not have the function of protein-coding. Studies have found that it can regulate gene expression at many levels, such as epigenetic level, transcriptional level and post-transcriptional level, thus affecting the occurrence and development of diseases. Recent studies have shown that the occurrence, development, of oral cancer, are associated with lncRNA. In this research, we found that lncRNA SNHG1 was up-regulated in oral cancer. Knockdown of lncRNA SNHG1 would inhibit the proliferation of oral cancer cells. Then we revealed a new mechanism that lncRNA SNHG1 regulated the growth of oral cancer via controlling the miR-421/HMGB2 axis, which provided new therapy for patients with oral cancer.
摘要：
口腔癌(OC)是口腔外科常见的恶性肿瘤。易发生转移,预后不容乐观。长链非编码RNA(lncRNA)是一类长度超过200bp的内源性转录物,缺乏具体和完整的开放阅读框架，并且不具有蛋白质编码功能。研究发现，它可以在许多水平上调节基因表达，比如表观遗传水平，转录水平和转录后水平，从而影响疾病的发生和发展。最近的研究表明,发展,口腔癌，与lncRNA相关。在这项研究中,我们发现lncRNASNHG1在口腔癌中表达上调.敲除lncRNASNHG1会抑制口腔癌细胞的增殖。然后我们揭示了一个新的机制，lncRNASNHG1通过控制miR-421/HMGB2轴调节口腔癌的生长，这为口腔癌患者提供了新的治疗方法。
