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Abstract：
Acral persistent papular mucinosis is a rare subtype of localized lichen myxedematosus. We report a case of a 41-year-old woman with acral persistent papular mucinosis. She had a 5-year history of multiple, scattered, whitish papules, on the back of both hands, of 2-5 mm in diameter. Histopathological examination revealed a focal, fairly circumscribed area with sparse collagen fibers in the upper and middle dermis. The circumscribed area was positively stained with Alcian blue. The papules were clinically and histologically diagnosed as acral persistent papular mucinosis. We also summarized 24 Japanese acral persistent papular mucinosis cases, including ours. Although acral persistent papular mucinosis occurs predominantly in women according to overseas reports, the male : female ratio is 5:7 in Japan. It has been reported that tranilast (N-[3,4-dimethoxycinnamoyl]-anthranilic acid) was effective in two Japanese cases. In our case, the patient had been treated with tranilast for 2 months without improvement. Further studies are required to confirm the efficacy of tranilast for acral persistent papular mucinosis.
摘要：
肢端持续性丘疹性黏液病是一种罕见的局部扁平苔藓粘液症亚型。我们报告了一例41岁的女性，患有肢端持续性丘疹性粘液病。她有5年的多发性病史,分散,发白的丘疹,双手背上,2-5毫米的直径。组织病理学检查显示有病灶,相当有限的区域，真皮上部和中部胶原纤维稀疏。限定区域被阿尔辛蓝阳性染色。丘疹在临床和组织学上被诊断为肢端持续性丘疹粘液病。我们还总结了24例日本的肢端持续丘疹粘液病病例，包括我们的.虽然据国外报道，肢端持续性丘疹黏液病主要发生在女性身上，日本的男女比例是5:7。据报道，曲尼司特（N-[3,4-二甲氧基肉桂酰基]-邻氨基苯甲酸）在两种日本病例中有效。在我们的案例中,患者接受曲尼司特治疗2个月,但无改善.需要进一步的研究来证实曲尼司特治疗肢端持续性丘疹粘液病的疗效。
