Abstract：
Cryptococcus is a basidiomycetous yeast responsible for considerable HIV-related morbidity and mortality. A cachectic 26-year-old HIV-positive man with a CD4 count of 103 cells/μl presented with fever, breathlessness, and bilateral lower limb weakness. A brain computed tomography scan could not elucidate the neurological deficit. His blood was sent for culture and serum cryptococcal antigen detection, with the latter testing as negative. By the fourth day of admission, the patient\'s condition had deteriorated drastically. A lumbar puncture was performed, and like his serum sample, the cerebrospinal fluid also tested negative for cryptococcal antigens. By this time, Cryptococcus neoformans was isolated from the admission blood culture. The laboratory diluted both the serum and cerebrospinal fluid specimens to retest for cryptococcal antigens, and finally, an antigen titer of ≥1:2560 was recorded.
摘要：
隐球菌是一种担子菌酵母，与HIV相关的发病率和死亡率相当高。一名26岁的恶病质HIV阳性男子，CD4计数为103个细胞/μl，伴有发烧，呼吸困难,和双侧下肢无力。脑部计算机断层扫描无法阐明神经功能缺损。他的血液被送去培养和血清隐球菌抗原检测，后者的测试为阴性。在入学的第四天，病人的病情急剧恶化。进行了腰椎穿刺,就像他的血清样本一样,脑脊液的隐球菌抗原也呈阴性。到这个时候,从入院血培养物中分离出新生隐球菌。实验室稀释血清和脑脊液标本以重新检测隐球菌抗原，最后，记录的抗原滴度≥1:2560.
