PDF(Pubmed)
Abstract：
BACKGROUND: Recent observations raised concern that the intravenous recombinant tissue plasminogen activator (rt-PA) may result in damage to stroke patients caused by small artery occlusion (SAO). Thus, we perform a protocol for meta-analysis to investigate the efficacy and safety of intravenous thrombolysis with rt-PA in SAO-patients.
METHODS: The search-style electronic libraries, including Pubmed, Embase, the Cochrane Library, Web of Science, Wanfang Data, VIP Chinese Journals, and China Biomedical Literature Service System are used for document retrieval in June 2021 with no restrictions on language. The risk of bias in include articles will be assessed using the Cochrane Risk of Bias Tool. We perform the meta-analysis by Stata version 10.0 software and calculated the statistics using the inverse variance statistical method. Binary outcomes are presented as Mantel-Haenszel-style risk ratios with 95% confidence interval. Continuous outcomes are reported as mean differences.
RESULTS: The results of the article will be shown in a peer-reviewed journal.
CONCLUSIONS: Intravenous rt-PA may be effective and safe in SAO-patients.
METHODS: The search-style electronic libraries, including Pubmed, Embase, the Cochrane Library, Web of Science, Wanfang Data, VIP Chinese Journals, and China Biomedical Literature Service System are used for document retrieval in June 2021 with no restrictions on language. The risk of bias in include articles will be assessed using the Cochrane Risk of Bias Tool. We perform the meta-analysis by Stata version 10.0 software and calculated the statistics using the inverse variance statistical method. Binary outcomes are presented as Mantel-Haenszel-style risk ratios with 95% confidence interval. Continuous outcomes are reported as mean differences.
RESULTS: The results of the article will be shown in a peer-reviewed journal.
CONCLUSIONS: Intravenous rt-PA may be effective and safe in SAO-patients.
摘要：
背景：最近的观察引起了人们的关注，即静脉内重组组织纤溶酶原激活剂（rt-PA）可能导致由小动脉闭塞（SAO）引起的中风患者的损害。因此，我们进行了一项meta分析方案,以研究rt-PA静脉溶栓在SAO患者中的疗效和安全性.
方法：搜索式电子图书馆，包括Pubmed,Embase,Cochrane图书馆,WebofScience,万方数据,VIP中文期刊,和中国生物医学文献服务系统于2021年6月进行文献检索，语言无限制。将使用Cochrane偏差风险工具评估包含文章中的偏差风险。我们使用Stata10.0版软件进行荟萃分析，并使用逆方差统计方法计算统计数据。二元结果表示为Mantel-Haenszel风格的风险比，置信区间为95％。连续结果报告为平均差异。
结果：文章的结果将在同行评审的期刊上显示。
结论：静脉rt-PA对SAO患者可能是有效和安全的。
方法：搜索式电子图书馆，包括Pubmed,Embase,Cochrane图书馆,WebofScience,万方数据,VIP中文期刊,和中国生物医学文献服务系统于2021年6月进行文献检索，语言无限制。将使用Cochrane偏差风险工具评估包含文章中的偏差风险。我们使用Stata10.0版软件进行荟萃分析，并使用逆方差统计方法计算统计数据。二元结果表示为Mantel-Haenszel风格的风险比，置信区间为95％。连续结果报告为平均差异。
结果：文章的结果将在同行评审的期刊上显示。
结论：静脉rt-PA对SAO患者可能是有效和安全的。
