PDF(Pubmed)
Abstract：
Background The pathogenesis and prognosis of multiple sclerosis (MS) is an area of active medical research. Dietary and biochemical parameters such as serum 25-dihydroxycholecalciferol, magnesium, and potassium play a role in disease progression. This study aimed to compare the nutritional status and biochemical profile of patients with and without MS. Methodology This case-control study included a total of 112 participants (56 in the control group and 56 in the MS group). The participants\' socioeconomic and demographic profiles, nutritional status, and biochemical details were all gathered using history, patient files, and records. The effect of these parameters on the presence of MS was evaluated using a decision tree model. Student\'s t-test and Mann-Whitney U test were performed to compare these parameters. Results A decision tree model was developed with an accuracy rate of 86.52%. The vitamin and mineral intake of the groups showed significant statistical differences (p = 0.001). The differences were important in terms of biochemical parameters, especially serum levels of 25-dihydroxycholecalciferol and potassium. Conclusions The key parameters that varied between MS patients and the control group, according to the constructed decision tree, were serum levels of 25-dihydroxycholecalciferol, magnesium, calcium, potassium, and carbohydrate intake. Nutritional measures against MS can be taken based on the decision tree.
摘要：
背景多发性硬化(MS)的发病机制和预后是一个活跃的医学研究领域。饮食和生化参数，如血清25-二羟基胆钙化醇，镁，钾在疾病进展中起作用。这项研究旨在比较患有和不患有MS的患者的营养状况和生化特征。方法本病例对照研究共包括112名参与者（对照组56名，MS组56名）。参与者的社会经济和人口概况，营养状况,生化细节都是用病史收集的，病人档案,和记录。使用决策树模型评估这些参数对MS存在的影响。进行学生t检验和Mann-WhitneyU检验以比较这些参数。结果建立了决策树模型,准确率为86.52%。各组的维生素和矿物质摄入量表现出显著的统计学差异(p=0.001)。在生化参数方面的差异很重要，尤其是25-二羟基胆钙化醇和钾的血清水平。结论MS患者和对照组之间的关键参数有所不同，根据构建的决策树，是25-二羟基胆钙化醇的血清水平，镁，钙，钾，和碳水化合物的摄入量。可以基于决策树采取针对MS的营养措施。
