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Abstract：
Purpose: To investigate the risk of recurrent corneal erosion (RCE) in patients with atopic keratoconjunctivitis (AKC). Methods: This national, retrospective, matched cohort study enrolled 184,166 newly-diagnosed AKC patients, selected from the Taiwan National Health Insurance Research Database and identified by the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) code 372.05. The control group comprised 184,166 non-AKC patients matched by age, sex, and potential comorbidities and they were selected from the Taiwan Longitudinal Health Insurance Database, 2000. Information from patients was gathered from 1 January 2004 to 31 December 2011, and both groups were traced from the index date until December 2013. The incidence and risk of RCE (ICD-9-CM code 361.42) was compared between the groups. The adjusted hazard ratio (HR) for RCE was obtained by a Cox proportional hazard regression analysis. The Kaplan-Meier analysis was performed to calculate the cumulative incidence of RCE. Results: In total, 564 AKC patients and 406 non-AKC controls developed RCE during the follow-up span. The incidence of RCE was 1.45 times higher in AKC patients than in controls (95% confidence interval [CI] = 1.27-1.64; P < 0.0001). After adjusting for potential confounders, including diabetes mellitus, keratoconjunctivitis sicca, corneal transplantation, ocular blunt trauma, corneal dystrophy, and band keratopathy, AKC patients were 1.36 times more likely to develop RCE than controls (adjusted HR, 1.36; 95% CI = 1.19-1.54; p < 0.05). Conclusions: AKC Patients had an increased risk of developing RCE and should be informed of this risk.
摘要：
目的：探讨特应性角膜结膜炎（AKC）患者复发性角膜糜烂（RCE）的风险。方法：这个国家，回顾性,配对队列研究纳入了184,166例新诊断的AKC患者，选自台湾国民健康保险研究数据库，并由国际疾病分类确定，第九次修订,临床修改(ICD-9-CM)代码372.05。对照组包括184,166名年龄相匹配的非AKC患者，性别,和潜在的合并症，它们是从台湾纵向健康保险数据库中选择的，2000.患者的信息收集时间为2004年1月1日至2011年12月31日，两组均从索引日期追踪至2013年12月。比较两组之间RCE的发生率和风险（ICD-9-CM代码361.42）。通过Cox比例风险回归分析获得RCE的校正风险比(HR)。进行Kaplan-Meier分析以计算RCE的累积发生率。结果：总的来说，564名AKC患者和406名非AKC对照在随访期间出现RCE。AKC患者的RCE发生率是对照组的1.45倍（95％置信区间[CI]=1.27-1.64；P<0.0001）。在调整了潜在的混杂因素后，包括糖尿病,干燥性角膜结膜炎，角膜移植,眼部钝性创伤,角膜营养不良,和带状角膜病变，AKC患者发生RCE的可能性是对照组的1.36倍(调整后的HR，1.36；95%CI=1.19-1.54；p<0.05）。结论：AKC患者发生RCE的风险增加，应告知此风险。
