关键词: anti-Hu antibody gallbladder carcinoma paraneoplastic neurological syndrome sensorimotor neuropathy

来  源:   DOI:10.5692/clinicalneurol.cn-001586

Abstract:
A 78-year-old woman experienced gait disturbance. She became unable to walk within a month. On admission, her cranial nerves were normal. She had motor weakness in the arms and legs, dysesthesia of the peripheral extremities, impaired deep sensation in the legs, and hyporeflexia in the arms and legs. She was initially diagnosed with Guillain-Barré syndrome; therefore, she was treated with intravenous immunoglobulin therapy and steroid mini-pulse therapy, however improvements of her neurological deficits were minimal. Anti-Hu antibody was positive in serum and gallbladder carcinoma was detected. She was treated with chemotherapy but neurological symptoms worsened progressively. Gallbladder carcinoma can rarely cause anti-Hu associated paraneoplastic sensorimotor neuropathy.
摘要:
一名78岁的妇女经历了步态障碍。她在一个月内无法行走。一入场,她的脑神经正常.她的胳膊和腿有运动无力,周围四肢的感觉异常,腿部深度感觉受损,手臂和腿部反射减退。她最初被诊断为格林-巴利综合征;因此,她接受了静脉注射免疫球蛋白疗法和类固醇小脉冲疗法,然而,她的神经功能缺损的改善很小。血清抗Hu抗体阳性,检出胆囊癌。她接受了化疗,但神经系统症状逐渐恶化。胆囊癌很少引起抗Hu相关的副肿瘤感觉运动神经病。
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