PDF(Pubmed)
Abstract：
UNASSIGNED: Cardiovascular disease (CVD), the leading cause of death worldwide is responsible for over 17 million deaths globally, of which 10 per cent deaths have been expected due to consumption of tobacco. The association between CVD and chewing of tobacco is limited and remains arguable. The aim of this study was to find out the correlation between urinary cotinine level and cardiovascular autonomic function tests of tobacco chewers.
UNASSIGNED: In the present study, 600 participants, 300 smokeless tobacco chewers (STC) and 300 non-tobacco chewers (NTC), between 18 and 65 yr were selected. Various parameters such as anthropometric, systolic blood pressure (SBP), diastolic blood pressure (DBP), autonomic function tests and urinary cotinine levels were measured.
UNASSIGNED: Significant difference (P<0.001) was noted in STC and NTC for anthropometric parameters, SBP, DBP and urinary cotinine levels. Sympathetic and parasympathetic autonomic function test showed significant difference on comparison in STC and NTC groups, except in Valsalva ratio. Correlations with urinary cotinine levels were significant for sympathetic autonomic functions, SBP fall (r=0.138, P=0.016), DBP rise (r=-0.141, P≤0.014); parasympathetic autonomic function, heart rate (HR) response to standing (r=-0.208, P≤0.003), deep breathing (r=-0.473, P≤0.001) and Valsalva ratio (r=-0.396, P≤0.0001).
UNASSIGNED: Correlation between urinary cotinine levels and autonomic function tests elucidates the linkage involving autonomic nervous system damage which can be considered as an important associated relationship for early diagnosis of CVD health risk factors among smokeless tobacco (ST) users.
UNASSIGNED: In the present study, 600 participants, 300 smokeless tobacco chewers (STC) and 300 non-tobacco chewers (NTC), between 18 and 65 yr were selected. Various parameters such as anthropometric, systolic blood pressure (SBP), diastolic blood pressure (DBP), autonomic function tests and urinary cotinine levels were measured.
UNASSIGNED: Significant difference (P<0.001) was noted in STC and NTC for anthropometric parameters, SBP, DBP and urinary cotinine levels. Sympathetic and parasympathetic autonomic function test showed significant difference on comparison in STC and NTC groups, except in Valsalva ratio. Correlations with urinary cotinine levels were significant for sympathetic autonomic functions, SBP fall (r=0.138, P=0.016), DBP rise (r=-0.141, P≤0.014); parasympathetic autonomic function, heart rate (HR) response to standing (r=-0.208, P≤0.003), deep breathing (r=-0.473, P≤0.001) and Valsalva ratio (r=-0.396, P≤0.0001).
UNASSIGNED: Correlation between urinary cotinine levels and autonomic function tests elucidates the linkage involving autonomic nervous system damage which can be considered as an important associated relationship for early diagnosis of CVD health risk factors among smokeless tobacco (ST) users.
摘要：
■心血管疾病（CVD），全球死亡的主要原因是全球超过1700万人死亡，预计其中10%的人因烟草消费而死亡。CVD和咀嚼烟草之间的关联是有限的并且仍然有争议。这项研究的目的是找出尿可替宁水平与烟草咀嚼者心血管自主神经功能测试之间的相关性。
■在本研究中，600名参与者，300个无烟烟草咀嚼器（STC）和300个非烟草咀嚼器（NTC），选择18至65岁。各种参数，如人体测量学，收缩压（SBP），舒张压（DBP），测量自主神经功能测试和尿可替宁水平。
■在STC和NTC中注意到人体测量参数的显着差异（P<0.001），SBP,DBP和尿可替宁水平。交感神经和副交感神经自主神经功能测试在STC和NTC组的比较中显示出显着差异。除了Valsalva比率。与尿可替宁水平的相关性对交感神经自主神经功能具有重要意义，SBP下降(r=0.138,P=0.016),DBP升高（r=-0.141，P≤0.014）；副交感神经自主神经功能，心率（HR）对站立的反应（r=-0.208，P≤0.003），深呼吸（r=-0.473，P≤0.001）和Valsalva比率（r=-0.396，P≤0.0001）。
■尿可替宁水平与自主功能测试之间的相关性阐明了涉及自主神经系统损害的联系，这可以被认为是无烟烟草（ST）使用者早期诊断CVD健康危险因素的重要关联关系。
■在本研究中，600名参与者，300个无烟烟草咀嚼器（STC）和300个非烟草咀嚼器（NTC），选择18至65岁。各种参数，如人体测量学，收缩压（SBP），舒张压（DBP），测量自主神经功能测试和尿可替宁水平。
■在STC和NTC中注意到人体测量参数的显着差异（P<0.001），SBP,DBP和尿可替宁水平。交感神经和副交感神经自主神经功能测试在STC和NTC组的比较中显示出显着差异。除了Valsalva比率。与尿可替宁水平的相关性对交感神经自主神经功能具有重要意义，SBP下降(r=0.138,P=0.016),DBP升高（r=-0.141，P≤0.014）；副交感神经自主神经功能，心率（HR）对站立的反应（r=-0.208，P≤0.003），深呼吸（r=-0.473，P≤0.001）和Valsalva比率（r=-0.396，P≤0.0001）。
■尿可替宁水平与自主功能测试之间的相关性阐明了涉及自主神经系统损害的联系，这可以被认为是无烟烟草（ST）使用者早期诊断CVD健康危险因素的重要关联关系。
