PDF(Pubmed)
Abstract：
Recent evidence has highlighted the critical role of memory cells in maintaining lifelong food allergies, thereby identifying these cells as therapeutic targets. IgG+ memory B cells replenish pools of IgE-secreting cells upon allergen exposure, which contract thereafter due to the short lifespan of tightly regulated IgE-expressing cells. Advances in the detection and highly dimensional analysis of allergen-specific B and T cells from allergic patients have provided insight on their phenotype and function. The newly identified Th2A and Tfh13 populations represent a leap in our understanding of allergen-specific T cell phenotypes, although how these populations contribute to IgE memory responses remains poorly understood. Within, we discuss the mechanisms by which memory B and T cells are activated, integrating knowledge from human systems and fundamental research. We then focus on memory reactivation, specifically, on the pathways of secondary IgE responses. Throughout, we identify areas of future research which will help identify immunotargets for a transformative therapy for food allergy.
摘要：
最近的证据强调了记忆细胞在维持终身食物过敏中的关键作用，从而将这些细胞鉴定为治疗靶标。IgG+记忆B细胞在过敏原暴露后补充IgE分泌细胞池，由于受到严格调控的IgE表达细胞的寿命较短，此后会收缩。来自过敏患者的过敏原特异性B和T细胞的检测和高度维度分析的进展提供了对其表型和功能的见解。新发现的Th2A和Tfh13群体代表了我们对过敏原特异性T细胞表型的理解的飞跃。尽管这些人群对IgE记忆反应的贡献尚不清楚。内,我们讨论了记忆B和T细胞被激活的机制，整合人类系统和基础研究的知识。然后我们专注于记忆的重新激活，具体来说,关于继发性IgE反应的途径。在整个过程中,我们确定了未来研究的领域，这将有助于确定食物过敏转化疗法的免疫目标。
