PDF(Pubmed)
Abstract：
UNASSIGNED: The influence of anesthetic method on the immune function and oxidative stress in patients receiving laparoscopic herniorrhaphy remains largely unknown.
UNASSIGNED: To assess the effects of different anesthetic methods on the immune function and oxidative stress in patients undergoing laparoscopic herniorrhaphy.
UNASSIGNED: A total of 280 eligible patients were randomly divided into two groups to receive total intravenous anesthesia (TIVA group) and inhalation anesthesia (IA group). T lymphocyte subsets, oxidative stress response indices and inflammatory factor levels were measured before anesthesia, at the end of the operation, and 1 and 3 days after the operation. The incidence rates of adverse reactions were compared.
UNASSIGNED: At the end of and 1 day after the operation, CD3+ and CD4+ T cells and CD4+/CD8+ decreased in both groups compared with those before anesthesia (p < 0.05). Three days after the operation, CD3+ and CD4+ T cells decreased in both groups compared with those before anesthesia, which were higher in the TIVA group (p < 0.05). Interleukin-6 and C-reactive protein levels were significantly lower in the TIVA group (p < 0.05). At the end of and 1 and 3 days after the operation, oxidative stress response indices superoxide dismutase, catalase and glutathione peroxidase declined in both groups compared with those before anesthesia, which were higher in the IA group (p < 0.05). The incidence rate of adverse reactions was significantly higher in the IA group (p = 0.002).
UNASSIGNED: Compared with IA, TIVA has less effect on the immune function and oxidative stress of patients undergoing laparoscopic herniorrhaphy, and controls the inflammatory response more effectively, accompanied by a lower incidence rate of adverse reactions.
UNASSIGNED: To assess the effects of different anesthetic methods on the immune function and oxidative stress in patients undergoing laparoscopic herniorrhaphy.
UNASSIGNED: A total of 280 eligible patients were randomly divided into two groups to receive total intravenous anesthesia (TIVA group) and inhalation anesthesia (IA group). T lymphocyte subsets, oxidative stress response indices and inflammatory factor levels were measured before anesthesia, at the end of the operation, and 1 and 3 days after the operation. The incidence rates of adverse reactions were compared.
UNASSIGNED: At the end of and 1 day after the operation, CD3+ and CD4+ T cells and CD4+/CD8+ decreased in both groups compared with those before anesthesia (p < 0.05). Three days after the operation, CD3+ and CD4+ T cells decreased in both groups compared with those before anesthesia, which were higher in the TIVA group (p < 0.05). Interleukin-6 and C-reactive protein levels were significantly lower in the TIVA group (p < 0.05). At the end of and 1 and 3 days after the operation, oxidative stress response indices superoxide dismutase, catalase and glutathione peroxidase declined in both groups compared with those before anesthesia, which were higher in the IA group (p < 0.05). The incidence rate of adverse reactions was significantly higher in the IA group (p = 0.002).
UNASSIGNED: Compared with IA, TIVA has less effect on the immune function and oxidative stress of patients undergoing laparoscopic herniorrhaphy, and controls the inflammatory response more effectively, accompanied by a lower incidence rate of adverse reactions.
摘要：
■麻醉方法对腹腔镜疝修补术患者的免疫功能和氧化应激的影响在很大程度上仍然未知。
■评估不同麻醉方法对腹腔镜疝修补术患者免疫功能和氧化应激的影响。
■共280例符合条件的患者随机分为两组，分别接受全静脉麻醉（TIVA组）和吸入麻醉（IA组）。T淋巴细胞亚群,麻醉前测定氧化应激反应指标和炎症因子水平,手术结束时,术后1天和3天。比较两组不良反应发生率。
■手术结束后1天，与麻醉前相比，两组CD3和CD4T细胞以及CD4/CD8均降低（p<0.05）。手术三天后,与麻醉前相比，两组患者的CD3+和CD4+T细胞均下降，在TIVA组中较高(p<0.05)。白细胞介素-6和C反应蛋白水平在TIVA组中显著降低(p<0.05)。手术结束后1天和3天，氧化应激反应指数超氧化物歧化酶，与麻醉前相比，两组过氧化氢酶和谷胱甘肽过氧化物酶均下降，IA组较高(p<0.05)。IA组的不良反应发生率明显高于IA组(p=0.002)。
■与IA相比，TIVA对腹腔镜疝修补术患者免疫功能和氧化应激的影响较小，更有效地控制炎症反应，伴随着较低的不良反应发生率。
■评估不同麻醉方法对腹腔镜疝修补术患者免疫功能和氧化应激的影响。
■共280例符合条件的患者随机分为两组，分别接受全静脉麻醉（TIVA组）和吸入麻醉（IA组）。T淋巴细胞亚群,麻醉前测定氧化应激反应指标和炎症因子水平,手术结束时,术后1天和3天。比较两组不良反应发生率。
■手术结束后1天，与麻醉前相比，两组CD3和CD4T细胞以及CD4/CD8均降低（p<0.05）。手术三天后,与麻醉前相比，两组患者的CD3+和CD4+T细胞均下降，在TIVA组中较高(p<0.05)。白细胞介素-6和C反应蛋白水平在TIVA组中显著降低(p<0.05)。手术结束后1天和3天，氧化应激反应指数超氧化物歧化酶，与麻醉前相比，两组过氧化氢酶和谷胱甘肽过氧化物酶均下降，IA组较高(p<0.05)。IA组的不良反应发生率明显高于IA组(p=0.002)。
■与IA相比，TIVA对腹腔镜疝修补术患者免疫功能和氧化应激的影响较小，更有效地控制炎症反应，伴随着较低的不良反应发生率。
