Abstract：
BACKGROUND: It has been shown that autonomic dysfunction in fibromyalgia can be assessed by the Composite Autonomic Symptom Score (COMPASS) questionnaire. More recently, a refined and much abbreviated 31-item version of the questionnaire has been developed, the COMPASS 31.
OBJECTIVE: The study has the following objectives: First, to determine whether the COMPASS 31 can assess changes in autonomic function in fibromyalgia. Second, to assess whether the COMPASS 31 values in fibromyalgia patients are positively correlated with scores on the Revised Fibromyalgia Impact Questionnaire (FIQR).
METHODS: A cross-sectional, case-controlled study was carried out with 25 fibromyalgia patients and 26 healthy controls.
RESULTS: The two groups were matched for age, sex and ethnicity, but not for body mass index (BMI). The total mean (standard error) COMPASS 31 for the fibromyalgia patients, 37.2 (1.8), differentiated the patients from the controls (9.5 (1.4); p < 0.00000001). The scores were greater in the fibromyalgia patients across all COMPASS 31 autonomic domains, namely orthostatic intolerance (p < 0.00000001), and vasomotor (p < 0.0001), secretomotor (p < 0.000001), gastrointestinal (p < 0.000001), bladder (p < 0.00001), and pupillomotor functions (p < 0.00000001). The total COMPASS 31 values were positively correlated with FIQR scores (rs = 0.45, p < 0.05). General linear modelling of the COMPASS 31 scores showed that only group status (fibromyalgia or control) was significant (p = 3.4 × 10-16), with age, sex and BMI being non-significant.
CONCLUSIONS: This study confirms that non-pain autonomic dysfunction symptoms occur in fibromyalgia and can be assessed with COMPASS 31.
OBJECTIVE: The study has the following objectives: First, to determine whether the COMPASS 31 can assess changes in autonomic function in fibromyalgia. Second, to assess whether the COMPASS 31 values in fibromyalgia patients are positively correlated with scores on the Revised Fibromyalgia Impact Questionnaire (FIQR).
METHODS: A cross-sectional, case-controlled study was carried out with 25 fibromyalgia patients and 26 healthy controls.
RESULTS: The two groups were matched for age, sex and ethnicity, but not for body mass index (BMI). The total mean (standard error) COMPASS 31 for the fibromyalgia patients, 37.2 (1.8), differentiated the patients from the controls (9.5 (1.4); p < 0.00000001). The scores were greater in the fibromyalgia patients across all COMPASS 31 autonomic domains, namely orthostatic intolerance (p < 0.00000001), and vasomotor (p < 0.0001), secretomotor (p < 0.000001), gastrointestinal (p < 0.000001), bladder (p < 0.00001), and pupillomotor functions (p < 0.00000001). The total COMPASS 31 values were positively correlated with FIQR scores (rs = 0.45, p < 0.05). General linear modelling of the COMPASS 31 scores showed that only group status (fibromyalgia or control) was significant (p = 3.4 × 10-16), with age, sex and BMI being non-significant.
CONCLUSIONS: This study confirms that non-pain autonomic dysfunction symptoms occur in fibromyalgia and can be assessed with COMPASS 31.
摘要：
背景：已经表明，纤维肌痛中的自主神经功能障碍可以通过复合自主神经症状评分（COMPASS）问卷进行评估。最近,已经开发了一个精致的、缩略得多的31项问卷版本，指南针31
目的：本研究有以下目的：以确定COMPASS31是否可以评估纤维肌痛中自主神经功能的变化。第二,评估纤维肌痛患者的COMPASS31值是否与修订的纤维肌痛影响问卷（FIQR）评分呈正相关。
方法：横截面，对25例纤维肌痛患者和26例健康对照者进行了病例对照研究。
结果：两组的年龄匹配，性别和种族,但不是体重指数（BMI）。纤维肌痛患者的总平均值（标准误差）COMPASS31，37.2(1.8),将患者与对照组区分开（9.5（1.4）；p<0.00000001）。所有COMPASS31自主神经域的纤维肌痛患者的得分更高，即直立不耐受(p<0.00000001)，和血管舒缩（p<0.0001），分泌运动（p<0.000001），胃肠道（p<0.000001），膀胱（p<0.00001），和瞳孔运动功能（p<0.00000001）。COMPASS31总分与FIQR评分呈正相关(rs=0.45,p<0.05)。COMPASS31评分的一般线性模型显示，只有组状态（纤维肌痛或对照）是显著的（p=3.4×10-16），随着年龄,性别和BMI不显著。
结论：这项研究证实纤维肌痛中出现非疼痛自主神经功能障碍症状，可以用COMPASS31进行评估。
目的：本研究有以下目的：以确定COMPASS31是否可以评估纤维肌痛中自主神经功能的变化。第二,评估纤维肌痛患者的COMPASS31值是否与修订的纤维肌痛影响问卷（FIQR）评分呈正相关。
方法：横截面，对25例纤维肌痛患者和26例健康对照者进行了病例对照研究。
结果：两组的年龄匹配，性别和种族,但不是体重指数（BMI）。纤维肌痛患者的总平均值（标准误差）COMPASS31，37.2(1.8),将患者与对照组区分开（9.5（1.4）；p<0.00000001）。所有COMPASS31自主神经域的纤维肌痛患者的得分更高，即直立不耐受(p<0.00000001)，和血管舒缩（p<0.0001），分泌运动（p<0.000001），胃肠道（p<0.000001），膀胱（p<0.00001），和瞳孔运动功能（p<0.00000001）。COMPASS31总分与FIQR评分呈正相关(rs=0.45,p<0.05)。COMPASS31评分的一般线性模型显示，只有组状态（纤维肌痛或对照）是显著的（p=3.4×10-16），随着年龄,性别和BMI不显著。
结论：这项研究证实纤维肌痛中出现非疼痛自主神经功能障碍症状，可以用COMPASS31进行评估。
