PDF(Pubmed)
Abstract：
BACKGROUND: Premature coronary artery disease (CAD) is still prevalent worldwide and may differ in various ethnicities. Due to the presence of different ethnicities in Iran, the Iran-premature coronary artery disease (I-PAD) study aimed to determine the frequency of premature CAD and related risk factors based on each ethnicity.
METHODS: In this multi-center case-control study, 4000 patients with premature CAD from ten different ethnicities who lived in different cities of Iran and underwent coronary angiography were enrolled (women aged ≤ 70 and men ≤ 60 years). Patients with CAD defined as obstruction equal or above 75% in at least a single coronary artery or left main ≥ 50% were included in the case group, while patients with normal coronary arteries were included in the control group. Lifestyle behaviors, cardiometabolic risk factors, anthropometric measurements, and other variables were collected. Serum, whole blood, buffy coat, plasma, urine, stool, and saliva samples were stored.
RESULTS: The number of patients enrolled until April 2020 was 2071. The mean age of patients was 53.51 ± 7.52 and 934 (45.09%) of patients were women. To date, about 39.6% of the patients were normal. Also, about 26.0% were with one-vessel disease (1VD), 15.0% with two-vessel disease (2VD), and 15.2% with three-vessel disease (3VD). More than 30000 patients\' biosamples from across the country have been stored.
CONCLUSIONS: Knowing the frequency of premature CAD according to different ethnicities with major differences in their lifestyle behaviors and risk factors can assist health decision-makers. In addition, I-PAD biosamples will be an invaluable source.
METHODS: In this multi-center case-control study, 4000 patients with premature CAD from ten different ethnicities who lived in different cities of Iran and underwent coronary angiography were enrolled (women aged ≤ 70 and men ≤ 60 years). Patients with CAD defined as obstruction equal or above 75% in at least a single coronary artery or left main ≥ 50% were included in the case group, while patients with normal coronary arteries were included in the control group. Lifestyle behaviors, cardiometabolic risk factors, anthropometric measurements, and other variables were collected. Serum, whole blood, buffy coat, plasma, urine, stool, and saliva samples were stored.
RESULTS: The number of patients enrolled until April 2020 was 2071. The mean age of patients was 53.51 ± 7.52 and 934 (45.09%) of patients were women. To date, about 39.6% of the patients were normal. Also, about 26.0% were with one-vessel disease (1VD), 15.0% with two-vessel disease (2VD), and 15.2% with three-vessel disease (3VD). More than 30000 patients\' biosamples from across the country have been stored.
CONCLUSIONS: Knowing the frequency of premature CAD according to different ethnicities with major differences in their lifestyle behaviors and risk factors can assist health decision-makers. In addition, I-PAD biosamples will be an invaluable source.
摘要：
背景：早发冠状动脉疾病（CAD）在全球范围内仍然很普遍，并且可能在不同种族之间存在差异。由于伊朗存在不同种族，伊朗-早发冠状动脉疾病(I-PAD)研究旨在根据每个种族确定早发CAD的频率和相关危险因素.
方法：在这项多中心病例对照研究中，来自10个不同种族的4000例早发CAD患者居住在伊朗不同城市，并接受了冠状动脉造影检查（女性≤70岁，男性≤60岁）。病例组包括至少单支冠状动脉阻塞等于或大于75%或左主干阻塞≥50%的CAD患者。将冠状动脉正常的患者纳入对照组。生活方式行为，心脏代谢危险因素，人体测量,和其他变量被收集。血清,全血,血沉棕黄层,等离子体,尿液,凳子,和唾液样本被储存。
结果：截至2020年4月的患者人数为2071。患者的平均年龄为53.51±7.52，女性患者为934（45.09％）。迄今为止,约39.6%的患者正常。此外，约26.0%患有单支血管疾病(1VD)，15.0％患有两管疾病（2VD），15.2%患有三支血管疾病(3VD)。来自全国各地的30000多名患者的生物样本已被储存。
结论：了解不同种族的早熟CAD的发生频率，以及他们的生活方式行为和危险因素的主要差异，可以帮助健康决策者。此外,I-PAD生物样品将是宝贵的来源。
方法：在这项多中心病例对照研究中，来自10个不同种族的4000例早发CAD患者居住在伊朗不同城市，并接受了冠状动脉造影检查（女性≤70岁，男性≤60岁）。病例组包括至少单支冠状动脉阻塞等于或大于75%或左主干阻塞≥50%的CAD患者。将冠状动脉正常的患者纳入对照组。生活方式行为，心脏代谢危险因素，人体测量,和其他变量被收集。血清,全血,血沉棕黄层,等离子体,尿液,凳子,和唾液样本被储存。
结果：截至2020年4月的患者人数为2071。患者的平均年龄为53.51±7.52，女性患者为934（45.09％）。迄今为止,约39.6%的患者正常。此外，约26.0%患有单支血管疾病(1VD)，15.0％患有两管疾病（2VD），15.2%患有三支血管疾病(3VD)。来自全国各地的30000多名患者的生物样本已被储存。
结论：了解不同种族的早熟CAD的发生频率，以及他们的生活方式行为和危险因素的主要差异，可以帮助健康决策者。此外,I-PAD生物样品将是宝贵的来源。
