关键词： AP, approved ASO, anti-streptolysin O BNP, brain-natriuretic peptide CDC, Center for Disease Control COVID-19 COVID-19, coronavirus disease 2019 CRP, C-reactive protein CXCL10, C-X-C-motif chemokine ligand 10 DCBLD2, Discoidin, CUB and LCCL domain-containing protein 2 E, envelope protein E.U., European Union ECMO, extracorporeal membrane oxygenation EKG, electrocardiogram EM, emergency use FDA, US Food and Drug Authority Fever GI, gastrointestinal IL, interleukin IVIG, intravenous immunoglobulin G Inflammation KD, Kawasaki disease LDH, lactate dehydrogenase LFTs, liver function tests M, membrane protein MIS-C MIS-C, Multisystem Inflammatory Syndrome in Children Mpred, methylprednisolone NP, Nucleoprotein PCR, polymerase chain reaction PT, prothrombin time PTT, partial thromboplastin time Pediatric RBD, receptor binding domain SARS-CoV-2 TE, thromboembolic events TNF, tumor necrosis factor TWEAK, TNF-like weak inducer of apoptosis U.S., United States of America VA, veno-arterial VLPs, virus-like particles VTE, venous thromboembolic events

来  源：   DOI：10.1016/j.ppedcard.2021.101407   PDF(Sci-hub)   PDF(Pubmed)

Abstract：
Multisystem inflammatory syndrome of children (MIS-C) continues to be a highly concerning diagnosis in those recently infected with SARS-CoV-2. The diagnosis of MIS-C cases will likely become even more challenging as vaccine uptake and natural immunity in previously infected persons leads to lower circulating rates of SARS-CoV-2 infection and will make cases sporadic. Febrile children presenting with cardiac dysfunction, symptoms overlapping Kawasaki disease or significant gastrointestinal complaints warrant a thorough screen in emergency departments, urgent care centers, and outpatient pediatric or family medicine practices. An increased index of suspicion and discussion regarding higher level of care (transferring to pediatric tertiary care centers or to intensive care) continues to be recommended. Herein we outline a broad approach with a multidisciplinary team for those meeting the case definition and believe such an approach is crucial for successful outcomes.
摘要：
在最近感染SARS-CoV-2的儿童中，儿童多系统炎症综合征（MIS-C）仍然是高度令人担忧的诊断。MIS-C病例的诊断可能会变得更具挑战性，因为先前感染者的疫苗摄取和天然免疫会导致SARS-CoV-2感染的循环率降低，并会使病例散发性。出现心功能不全的发热儿童，与川崎病重叠的症状或严重的胃肠道投诉需要在急诊科进行彻底的筛查，紧急护理中心,和门诊儿科或家庭医学实践。继续建议增加对更高水平护理（转移到儿科三级护理中心或重症监护）的怀疑和讨论指数。在这里，我们概述了一个多学科团队的广泛方法，以满足案例定义，并相信这种方法对于成功的结果至关重要。
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