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Abstract：
Schistosoma mansoni worms are under a milieu of external and internal signaling pathways. The life-cycle stages are exposed to enormous stimuli within the mammalian and the snail hosts and as free-living stages in the fresh water. Furthermore, there is a unique interplay between the male and the female worms involving many stimuli from the male essential for full development of the female. PI3K/Akt/mTOR is an evolutionarily divergent signal transduction pathway universal to nearly every multicellular organism. This work reviews the Schistosoma mansoni PI3K/Akt/mTOR signal pathways and the involvement of the signal in the worms\' physiology concerning the uptake of glucose, reproduction and survival. The inhibitors of the signal pathway used against Schistosoma mansoni were summarized. Given the importance of the PI3K/Akt/mTOR signal pathway, its inhibition could be a promising control strategy against schistosomiasis.
摘要：
曼氏血吸虫蠕虫处于外部和内部信号通路的环境下。生命周期阶段在哺乳动物和蜗牛宿主中受到巨大的刺激，并在淡水中作为自由生活阶段。此外，有一个独特的相互作用之间的男性和女性的蠕虫涉及许多刺激，从男性必不可少的充分发展的女性。PI3K/Akt/mTOR是几乎所有多细胞生物体通用的进化上不同的信号转导途径。这项工作回顾了曼氏血吸虫PI3K/Akt/mTOR信号通路以及信号在蠕虫生理中的参与，涉及葡萄糖的摄取，繁殖和生存。总结了针对曼氏血吸虫的信号通路抑制剂。鉴于PI3K/Akt/mTOR信号通路的重要性，其抑制作用可能是一种有希望的血吸虫病控制策略。
