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Abstract：
This study examined the moderation of an oxytocin receptor (OXTR) gene in the link between childhood adversity and depressive symptoms among incarcerated males.
Questionnaires about adverse childhood experiences and depressive symptoms, as well as genomic DNA from blood were collected among 608 incarcerated males (Mage = 32.4 years, SD = 9.41, 18-74 years). Moderation analysis was applied to examine the interaction between adverse childhood experiences (including abuse, neglect, and household dysfunction) and the OXTR polymorphisms (rs2254298, rs53576) in predicting depressive symptoms.
Incarcerated males had relatively higher prevalence of childhood adversity (70.2%) and depressive symptoms (49.8%). Higher childhood adversity was associated with increased depressive symptoms, and the effect was more pronounced in the GG homozygotes of OXTR rs2254298 (b = 0.406, p < .001), as compared with the AA/AG carriers (b = 0.236, p < .001). By contrast, the OXTR rs53576 did not interact with childhood adversity in predicting depressive symptoms.
Chinese incarcerated males with the GG genotype of OXTR rs2254298 have higher vulnerability in the effect of childhood adversity on depressive symptoms.
Questionnaires about adverse childhood experiences and depressive symptoms, as well as genomic DNA from blood were collected among 608 incarcerated males (Mage = 32.4 years, SD = 9.41, 18-74 years). Moderation analysis was applied to examine the interaction between adverse childhood experiences (including abuse, neglect, and household dysfunction) and the OXTR polymorphisms (rs2254298, rs53576) in predicting depressive symptoms.
Incarcerated males had relatively higher prevalence of childhood adversity (70.2%) and depressive symptoms (49.8%). Higher childhood adversity was associated with increased depressive symptoms, and the effect was more pronounced in the GG homozygotes of OXTR rs2254298 (b = 0.406, p < .001), as compared with the AA/AG carriers (b = 0.236, p < .001). By contrast, the OXTR rs53576 did not interact with childhood adversity in predicting depressive symptoms.
Chinese incarcerated males with the GG genotype of OXTR rs2254298 have higher vulnerability in the effect of childhood adversity on depressive symptoms.
摘要：
这项研究检查了催产素受体（OXTR）基因在儿童逆境与被监禁男性抑郁症状之间的联系中的调节作用。
关于不良童年经历和抑郁症状的问卷调查，在608名被监禁的男性中收集了血液中的基因组DNA(Mage=32.4岁，SD=9.41，18-74岁）。适度分析用于检查不良童年经历(包括虐待，疏忽,和家庭功能障碍）和预测抑郁症状的OXTR多态性（rs2254298，rs53576）。
被监禁的男性儿童逆境(70.2%)和抑郁症状(49.8%)的患病率相对较高。较高的儿童逆境与抑郁症状增加有关，并且在OXTRrs2254298的GG纯合子中效果更明显（b=0.406，p<.001），与AA/AG载波相比(b=0.236，p<.001)。相比之下,OXTRrs53576在预测抑郁症状方面与儿童逆境无关.
GG基因型为OXTRrs2254298的中国男性在儿童期逆境对抑郁症状的影响中具有更高的脆弱性。
关于不良童年经历和抑郁症状的问卷调查，在608名被监禁的男性中收集了血液中的基因组DNA(Mage=32.4岁，SD=9.41，18-74岁）。适度分析用于检查不良童年经历(包括虐待，疏忽,和家庭功能障碍）和预测抑郁症状的OXTR多态性（rs2254298，rs53576）。
被监禁的男性儿童逆境(70.2%)和抑郁症状(49.8%)的患病率相对较高。较高的儿童逆境与抑郁症状增加有关，并且在OXTRrs2254298的GG纯合子中效果更明显（b=0.406，p<.001），与AA/AG载波相比(b=0.236，p<.001)。相比之下,OXTRrs53576在预测抑郁症状方面与儿童逆境无关.
GG基因型为OXTRrs2254298的中国男性在儿童期逆境对抑郁症状的影响中具有更高的脆弱性。
