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Abstract：
Intracellular platelet activating-factor acetylhydrolase type II (PAF-AH II) is a 40-kDa monomeric enzyme. It was originally identified as an enzyme that hydrolyzes the acetyl group of PAF (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine). As a member of phospholipase A2 super family, PAF-AH II has broad substrate specificity. It can hydrolyze phospholipids with relatively short-length or oxidatively modified sn-2 chains which endows it with various functions such as protection against oxidative stress, transacetylase activity and producing lipid mediators. PAF-AH II has been proven to be involved in several diseases such as allergic diseases, oxidative stress-induced injury and ischemia injury, thus it has drawn more attention from researchers. In this paper, we outline an entire summary of PAF-AH II, including its structure, substrate specificity, activity assay, inhibitors and biological activities.
摘要：
细胞内血小板活化因子乙酰水解酶II型（PAF-AHII）是一种40kDa的单体酶。它最初被鉴定为水解PAF的乙酰基（1-O-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱）的酶。作为磷脂酶A2超家族的一员，PAF-AHII具有广泛的底物特异性。它可以水解具有相对较短长度或氧化修饰的sn-2链的磷脂，这使其具有各种功能，例如防止氧化应激，转乙酰酶活性和产生脂质介质。PAF-AHII已被证明与多种疾病有关，例如过敏性疾病，氧化应激损伤和缺血损伤,因此，它引起了研究人员的更多关注。在本文中,我们概述了PAF-AHII的完整摘要，包括它的结构，底物特异性，活性测定，抑制剂和生物活性。
