Reversible splenial lesion syndrome in sisters with sensorineural deafness as the first manifestation.

以感觉神经性耳聋为首发表现的姐妹可逆性脾病变综合征。

• 影响指数: 3.776
• 发表时间: May 2021
• 来源期刊: Heliyon
• DOI: 10.1016/j.heliyon.2021.e07057
• PMID: 34113728
• 文章类型: Case Reports
• 作者列表: Yang J,Ma X,Li R,Ma X,Chen J,Zhang X

关键词: Corpus callosum; Reversible splenial lesion syndrome; Sensorineural deafness

Abstract

Reversible splenial lesion syndrome (RESLES) is a rare clinico-radiological disorder syndrome with unclear pathophysiology. Here, two sisters with sensorineural deafness as the chief complaint diagnosed with RESLES was reported. Although the sisters had the disease successively, they were divided into two types on imaging by isolated lesions of splenium of the corpus callosum (SCC) and extensive lesions of the corpus callosum. The clinical manifestations and lesions on MRI disappeared after 6 months. The sensorineural deafness of the sisters in this article may be caused by transcallosal auditory pathway (TCAP) injury. Auditory handicap has been found in previous RESLES cases, indicating that we know little about the connection between the SCC and the auditory pathway, and further research is needed.

摘要

可逆性脾病变综合征（RESLES）是一种罕见的临床放射学疾病综合征，其病理生理学尚不清楚。这里,据报道，两名姐妹以感觉神经性耳聋为主要主诉，被诊断为RESLES。尽管姐妹们相继患病，根据孤立的call体（SCC）脾病变和call体广泛病变，它们在影像学上分为两种类型。6个月后MRI临床表现及病灶消失。本文姐妹的感音神经性耳聋可能是由跨call听觉通路（TCAP）损伤引起的。在以前的RESLES病例中发现了听觉障碍，表明我们对SCC和听觉通路之间的联系知之甚少，需要进一步的研究。