PDF(Pubmed)
Abstract：
Cerium (Ce), the most abundant of rare earth elements in the earth\'s crust, has received much health concerns due to its wide application in industry, agriculture, and medicine. The current study aims to evaluate whether there is an association between Ce exposures and the risk of developing oral cancer. Serum Ce level of 324 oral cancer patients and 650 matched healthy controls were measured by inductively coupled plasma mass spectrometry. Association between Ce level and the risk of oral cancer was estimated with an unconditional logistic regression model. Serum Ce concentrations in the oral cancer patients and controls were 0.57 (0.21-3.02) μg/L and 2.27 (0.72-4.26) μg/L, respectively. High level of Ce was associated with a decreased risk of oral cancer (OR: 0.60, 95% CI: 0.43-0.84). Stronger inverse associations between high level of Ce and oral cancer risk were observed among those with smoking (OR: 0.46, 95% CI: 0.27-0.79), drinking (OR: 0.50, 95% CI: 0.26-0.96), limited intake of leafy vegetables (OR: 0.40, 95% CI: 0.22-0.71) and fish (OR: 0.52, 95% CI: 0.33-0.83). There were significant multiplicative interactions between Ce level and alcohol drinking or intake of leafy vegetables and fish (all Pinteraction <0.05). This preliminary case-control study suggests an inverse association between high serum Ce level and the risk of oral cancer. Further prospective studies with a larger sample size are needed to confirm the findings.
摘要：
铈(Ce),地壳中最丰富的稀土元素，由于其在工业中的广泛应用，受到了许多健康问题的关注，农业,和医学。目前的研究旨在评估Ce暴露与患口腔癌的风险之间是否存在关联。采用电感耦合等离子体质谱法测定了324例口腔癌患者和650例健康对照者的血清Ce水平。使用非条件逻辑回归模型估计Ce水平与口腔癌风险之间的关联。口腔癌患者和对照组的血清Ce浓度分别为0.57（0.21-3.02）μg/L和2.27（0.72-4.26）μg/L。分别。高Ce水平与口腔癌风险降低相关(OR:0.60,95%CI:0.43-0.84)。在吸烟人群中观察到高Ce水平与口腔癌风险之间有更强的负相关（OR：0.46，95％CI：0.27-0.79），饮酒（OR：0.50，95%CI：0.26-0.96），限制摄入叶类蔬菜(OR:0.40,95%CI:0.22-0.71)和鱼类(OR:0.52,95%CI:0.33-0.83)。Ce水平与饮酒或叶菜类蔬菜和鱼类的摄入量之间存在显着的倍增相互作用（所有P相互作用<0.05）。这项初步的病例对照研究表明，高血清Ce水平与口腔癌的风险呈负相关。需要更大样本量的进一步前瞻性研究来证实这一发现。
