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Abstract：
UNASSIGNED: Streptococcus agalactiae, a species of β-haemolytic streptococcus belonging to Lancefield\'s group B (GBS), is known as a common infecting agent transmitted to infants during childbirth, causing sepsis, meningitis, or both, with a high incidence of mortality. Following the observation of a great variability between regional laboratories both in the methodology and in the results of tests for the detection of GBS in pregnancy, with high percentages of false negative results, in 2010 the Department for Health Policies of Piedmont, Italian region, issued specific recommendations for adhere to international guidelines. Our aim was to assess whether the impact of the publication of the recommendations has been lasting over time.
UNASSIGNED: We analyzed the regional birth certificate register from 2006 to 2018, to evaluate the annual number of deliveries, the number of Streptococcus agalactiae tests in pregnancy and the percentage of positive culture results. We also evaluated the consistency of the percentage of positive tests with the expectations based on the guidelines and compared the two time periods before and after introduction of regional recommendations using a multivariate regression model.
UNASSIGNED: The mean proportion of women tested for GBS vaginal-rectal swabs during pregnancy increased from 83.5% in 2006 to 90.7% in 2018 with the biggest rise in 2010, the t-test for the comparison of the two means was statistically significant (p < .001). The mean positivity rate increased from 12.7% to 19.2%, with a rise in 2010, with a significant t-test (p < .001).
UNASSIGNED: The results suggested a significant impact of the recommendations on the compliance and results regarding the carrying out and culture of vagino-rectal swabs for GBS, with better appropriateness of peripartum antibiotic therapy and possible reduction of GBS related neonatal sepsis.
UNASSIGNED: We analyzed the regional birth certificate register from 2006 to 2018, to evaluate the annual number of deliveries, the number of Streptococcus agalactiae tests in pregnancy and the percentage of positive culture results. We also evaluated the consistency of the percentage of positive tests with the expectations based on the guidelines and compared the two time periods before and after introduction of regional recommendations using a multivariate regression model.
UNASSIGNED: The mean proportion of women tested for GBS vaginal-rectal swabs during pregnancy increased from 83.5% in 2006 to 90.7% in 2018 with the biggest rise in 2010, the t-test for the comparison of the two means was statistically significant (p < .001). The mean positivity rate increased from 12.7% to 19.2%, with a rise in 2010, with a significant t-test (p < .001).
UNASSIGNED: The results suggested a significant impact of the recommendations on the compliance and results regarding the carrying out and culture of vagino-rectal swabs for GBS, with better appropriateness of peripartum antibiotic therapy and possible reduction of GBS related neonatal sepsis.
摘要：
■无乳链球菌，属于LancefieldB组（GBS）的一种β-溶血性链球菌，被称为在分娩过程中传播给婴儿的常见感染因子，引起脓毒症,脑膜炎,或者两者兼而有之,死亡率很高。在观察到区域实验室之间在方法和妊娠GBS检测测试结果方面存在很大差异之后，假阴性结果的百分比很高，2010年，皮埃蒙特卫生政策部，意大利地区,发表了遵守国际准则的具体建议。我们的目的是评估发布建议的影响是否随着时间的推移而持续。
■我们分析了2006年至2018年的地区出生证明登记册，以评估年度分娩次数，妊娠无乳链球菌检测的数量和培养结果阳性的百分比。我们还根据指南评估了阳性测试百分比与预期的一致性，并使用多元回归模型比较了引入区域建议前后的两个时间段。
■怀孕期间接受GBS阴道直肠拭子检查的女性平均比例从2006年的83.5％增加到2018年的90.7％，2010年的增幅最大，t检验两种方法的比较具有统计学意义（p<.001）。平均阳性率从12.7%上升到19.2%，2010年上升，有显著的t检验(p<.001)。
■结果表明，建议对GBS的阴道直肠拭子的实施和培养的依从性和结果产生重大影响，与更好的适当的围产期抗生素治疗和可能减少GBS相关的新生儿败血症。
■我们分析了2006年至2018年的地区出生证明登记册，以评估年度分娩次数，妊娠无乳链球菌检测的数量和培养结果阳性的百分比。我们还根据指南评估了阳性测试百分比与预期的一致性，并使用多元回归模型比较了引入区域建议前后的两个时间段。
■怀孕期间接受GBS阴道直肠拭子检查的女性平均比例从2006年的83.5％增加到2018年的90.7％，2010年的增幅最大，t检验两种方法的比较具有统计学意义（p<.001）。平均阳性率从12.7%上升到19.2%，2010年上升，有显著的t检验(p<.001)。
■结果表明，建议对GBS的阴道直肠拭子的实施和培养的依从性和结果产生重大影响，与更好的适当的围产期抗生素治疗和可能减少GBS相关的新生儿败血症。
