Abstract：
We examined maternal prenatal vitamin use or supplemental folic acid intake during month one of pregnancy for association with autism spectrum disorder (ASD) in the Early Autism Risk Longitudinal Investigation, an enriched-risk pregnancy cohort. Total folic acid intake was calculated from monthly prenatal vitamins, multivitamins, and other supplement reports. Clinical assessments through age 3 years classified children as ASD (n = 38) or non-ASD (n = 153). In pregnancy month one, prenatal vitamin use (59.7%) was not significantly associated with odds of ASD (OR = 0.70, 95%CI 0.32, 1.53). Sample size was limited and residual confounding was possible. Given the estimated effect sizes in this and previous work, prenatal vitamin intake during early pregnancy could be a clinically useful preventative measure for ASD.
摘要：
在早期自闭症风险纵向调查中，我们检查了孕妇在怀孕1个月期间的产前维生素使用或补充叶酸摄入与自闭症谱系障碍（ASD）的关联。丰富的妊娠风险队列。总叶酸摄入量是根据每月产前维生素计算的，多种维生素,以及其他补充报告。3岁以下的临床评估将儿童分为ASD（n=38）或非ASD（n=153）。在怀孕的第一个月，产前维生素使用(59.7%)与ASD的几率无显著相关(OR=0.70,95CI0.32,1.53).样本量有限，并且可能存在残留的混杂因素。鉴于本工作和先前工作中的估计效果大小，妊娠早期产前维生素摄入量可能是一项临床有用的ASD预防措施.
