PDF(Sci-hub)
Abstract：
Owing to its rarity and heterogeneity, the biological behavior and optimal therapeutic management of mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) have not been established. Herein, we aimed to evaluate the clinicopathological characteristics and metastatic patterns of MiNEN.
Continuous clinicopathological data of MiNEN patients treated at our hospital were retrospectively collected and analyzed.
This study had enrolled 169 patients since January 2010 to January 2020. Pathological components were assessed in 129 patients with MiNEN (76.3%), and a focal (non-)neuroendocrine component was observed in 40 patients (23.7%; <30% of the tumor). Among the enrolled patients, 80 underwent surgical removal of the primary tumor and lymph nodes (LNs), and 34 with distant metastasis underwent biopsy of both primary tumor and metastatic lesions. In patients with LN metastasis, 68.8% (55/80) exhibited a pure component of either neuroendocrine (NE) or adenocarcinoma/squamous carcinoma (AS) in metastatic LNs, while 20% (16/80) showed different components in different LNs, and only 11.2% (9/80) exhibited both NE and AS components in the same LN. In patients with distant metastases, 26.5% (9/34) possessed coexisting NE and AS components in the distant metastases, 70.6% (24/34) were regarded as a pure NE component, and 2.9% (1/34) were comprised of a pure AS component.
Lymph node and distant metastases exhibited distinct metastatic patterns in patients with MiNEN. The major pathological component in regional LNs may have influenced the proportion of the two components within the primary tumor, but distant metastases were dominated by the NE component.
Continuous clinicopathological data of MiNEN patients treated at our hospital were retrospectively collected and analyzed.
This study had enrolled 169 patients since January 2010 to January 2020. Pathological components were assessed in 129 patients with MiNEN (76.3%), and a focal (non-)neuroendocrine component was observed in 40 patients (23.7%; <30% of the tumor). Among the enrolled patients, 80 underwent surgical removal of the primary tumor and lymph nodes (LNs), and 34 with distant metastasis underwent biopsy of both primary tumor and metastatic lesions. In patients with LN metastasis, 68.8% (55/80) exhibited a pure component of either neuroendocrine (NE) or adenocarcinoma/squamous carcinoma (AS) in metastatic LNs, while 20% (16/80) showed different components in different LNs, and only 11.2% (9/80) exhibited both NE and AS components in the same LN. In patients with distant metastases, 26.5% (9/34) possessed coexisting NE and AS components in the distant metastases, 70.6% (24/34) were regarded as a pure NE component, and 2.9% (1/34) were comprised of a pure AS component.
Lymph node and distant metastases exhibited distinct metastatic patterns in patients with MiNEN. The major pathological component in regional LNs may have influenced the proportion of the two components within the primary tumor, but distant metastases were dominated by the NE component.
摘要：
由于其稀有性和异质性，混合性神经内分泌-非神经内分泌肿瘤(MiNEN)的生物学行为和最佳治疗管理尚未确定.在这里，我们旨在评估MiNEN的临床病理特征和转移模式。
回顾性收集并分析在我院接受治疗的MiNEN患者的连续临床病理资料。
自2010年1月至2020年1月，这项研究共纳入169名患者。对129例MiNEN患者（76.3%）的病理成分进行了评估，在40例患者中观察到局灶性（非）神经内分泌成分（23.7％；<30％的肿瘤）。在登记的患者中，80例接受了原发肿瘤和淋巴结（LNs）的手术切除，34例远处转移患者接受了原发肿瘤和转移灶的活检。在有LN转移的患者中，68.8％（55/80）在转移性LN中表现出神经内分泌（NE）或腺癌/鳞状细胞癌（AS）的纯成分，而20%(16/80)在不同的LN中表现出不同的成分，只有11.2%(9/80)在同一LN中同时表现出NE和AS组分。在远处转移的患者中，26.5％（9/34）在远处转移中具有共存的NE和AS成分，70.6%(24/34)被认为是纯NE组分，2.9%(1/34)由纯AS组分组成。
在MiNEN患者中，淋巴结和远处转移表现出不同的转移模式。区域LN中的主要病理成分可能影响了原发性肿瘤中两种成分的比例，但远处转移以NE成分为主。
回顾性收集并分析在我院接受治疗的MiNEN患者的连续临床病理资料。
自2010年1月至2020年1月，这项研究共纳入169名患者。对129例MiNEN患者（76.3%）的病理成分进行了评估，在40例患者中观察到局灶性（非）神经内分泌成分（23.7％；<30％的肿瘤）。在登记的患者中，80例接受了原发肿瘤和淋巴结（LNs）的手术切除，34例远处转移患者接受了原发肿瘤和转移灶的活检。在有LN转移的患者中，68.8％（55/80）在转移性LN中表现出神经内分泌（NE）或腺癌/鳞状细胞癌（AS）的纯成分，而20%(16/80)在不同的LN中表现出不同的成分，只有11.2%(9/80)在同一LN中同时表现出NE和AS组分。在远处转移的患者中，26.5％（9/34）在远处转移中具有共存的NE和AS成分，70.6%(24/34)被认为是纯NE组分，2.9%(1/34)由纯AS组分组成。
在MiNEN患者中，淋巴结和远处转移表现出不同的转移模式。区域LN中的主要病理成分可能影响了原发性肿瘤中两种成分的比例，但远处转移以NE成分为主。
