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Abstract：
OBJECTIVE: Hyperemesis gravidarum is an illness that starts in early pregnancy and manifests itself with oral intake problems, electrolyte imbalance, ketonuria, and weight loss. Inflammation is closely associated with the hyperemesis gravidarum, and inflammatory indicators have been studied to understand its pathophysiology. This study investigates the relationship of ketonuria levels with inflammatory markers platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and neutrophil-to-lymphocyte ratio (NLR) for hyperemesis gravidarum patients.
METHODS: This retrospective case control study was conducted at Kütahya Medical Sciences University Tertiary Research and Training Hospital between December 2019 and December 2020. A total of 173 pregnancies, 82 of them with hyperemesis gravidarum and 91 of them low-risk pregnancies were included in the study. The patients\' demographic profiles and laboratory parameters were recorded. The patients were divided into hyperemesis gravidarum and control groups and the groups were compared for the levels of inflammation markers. For the hyperemesis gravidarum group, the relationship between ketonuria levels and the inflammation severity was investigated.
RESULTS: MLR, NLR, PLR levels were higher in the hyperemesis gravidarum group than the control group in a statistically significant way (p < 0.001 for all of the comparisons). The hyperemesis gravidarum group was subdivided into four groups based on their ketonuria levels, and their MLR, NLR, PLR levels were compared. The differences between the groups were statistically significant (p < 0.001) and the indicators increased with the ketonuria levels. Finally, ketonuria levels had a positive and significant correlation with MLR (rho =0.67, p < 0.001), PLR (rho =0.67, p < 0.001), and NLR (rho =0.8, p < 0.001).
CONCLUSIONS: Hyperemesis gravidarum patients have higher levels of hematologic inflammation indicators than healthy pregnant patients. For these patients, the levels of the indicators increase with ketonuria levels.
METHODS: This retrospective case control study was conducted at Kütahya Medical Sciences University Tertiary Research and Training Hospital between December 2019 and December 2020. A total of 173 pregnancies, 82 of them with hyperemesis gravidarum and 91 of them low-risk pregnancies were included in the study. The patients\' demographic profiles and laboratory parameters were recorded. The patients were divided into hyperemesis gravidarum and control groups and the groups were compared for the levels of inflammation markers. For the hyperemesis gravidarum group, the relationship between ketonuria levels and the inflammation severity was investigated.
RESULTS: MLR, NLR, PLR levels were higher in the hyperemesis gravidarum group than the control group in a statistically significant way (p < 0.001 for all of the comparisons). The hyperemesis gravidarum group was subdivided into four groups based on their ketonuria levels, and their MLR, NLR, PLR levels were compared. The differences between the groups were statistically significant (p < 0.001) and the indicators increased with the ketonuria levels. Finally, ketonuria levels had a positive and significant correlation with MLR (rho =0.67, p < 0.001), PLR (rho =0.67, p < 0.001), and NLR (rho =0.8, p < 0.001).
CONCLUSIONS: Hyperemesis gravidarum patients have higher levels of hematologic inflammation indicators than healthy pregnant patients. For these patients, the levels of the indicators increase with ketonuria levels.
摘要：
目的：妊娠剧吐是一种开始于妊娠早期并表现为口服摄入问题的疾病，电解质不平衡，酮尿症,和减肥。炎症与妊娠剧吐密切相关，和炎症指标已被研究以了解其病理生理学。这项研究调查了酮症尿症水平与炎症标志物血小板淋巴细胞比率（PLR）的关系，单核细胞与淋巴细胞比率（MLR），妊娠剧吐患者的中性粒细胞与淋巴细胞比率（NLR）。
方法：这项回顾性病例对照研究于2019年12月至2020年12月在Kutahya医科大学三级研究和培训医院进行。共有173次怀孕，研究中包括82例妊娠剧吐和91例低风险妊娠。记录患者的人口统计学特征和实验室参数。将患者分为妊娠剧吐组和对照组，并比较两组的炎症标志物水平。对于妊娠剧吐组，研究了酮尿症水平与炎症严重程度之间的关系.
结果：MLR，NLR,妊娠剧吐组的PLR水平高于对照组，具有统计学意义（所有比较的p<0.001）。妊娠剧吐组根据酮尿症水平分为四组，和他们的MLR，NLR,比较PLR水平。组间差异有统计学意义（p<0.001），且指标随着酮尿症水平的增加而增加。最后,酮尿症水平与MLR呈正相关(rho=0.67,p<0.001),PLR（rho=0.67，p<0.001），和NLR(rho=0.8,p<0.001)。
结论：妊娠剧吐患者血液炎症指标水平高于健康孕妇。对于这些患者来说,指标水平随着酮尿症水平的增加而增加。
方法：这项回顾性病例对照研究于2019年12月至2020年12月在Kutahya医科大学三级研究和培训医院进行。共有173次怀孕，研究中包括82例妊娠剧吐和91例低风险妊娠。记录患者的人口统计学特征和实验室参数。将患者分为妊娠剧吐组和对照组，并比较两组的炎症标志物水平。对于妊娠剧吐组，研究了酮尿症水平与炎症严重程度之间的关系.
结果：MLR，NLR,妊娠剧吐组的PLR水平高于对照组，具有统计学意义（所有比较的p<0.001）。妊娠剧吐组根据酮尿症水平分为四组，和他们的MLR，NLR,比较PLR水平。组间差异有统计学意义（p<0.001），且指标随着酮尿症水平的增加而增加。最后,酮尿症水平与MLR呈正相关(rho=0.67,p<0.001),PLR（rho=0.67，p<0.001），和NLR(rho=0.8,p<0.001)。
结论：妊娠剧吐患者血液炎症指标水平高于健康孕妇。对于这些患者来说,指标水平随着酮尿症水平的增加而增加。
