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Abstract：
Liposomal honokiol isolated from the genus Magnolia has been found to have antiangiogenic, anti-inflammatory and antitumor properties. However, there has no report on its role in hair growth. Hair follicles are life-long cycled organelles that go through from anagen, catagen and telogen stages and are regulated by diverse signaling pathways, including Wnt/β-catenin, Notch, Epidermal growth factor (EGF) and Sonic hegehog (SHH). Wnt signals are essential for the initiation of hair follicle placode development and a new potential target of hair loss treatment. This study was designed to investigate the effect of liposomal honokiol (Lip-honokiol) on inducing hair anagen. We identified the hair grew out in advance in the shaving area of C57BL/6N mice after the treatment of liposomal honokiol (Lip-honokiol) by daily abdominal injection. We first demonstrated that Lip-Honokiol activated the Wnt3a/β-catenin pathway and downregulated the transforming growth factor-β1 (TGF-β1) to promote hair growth in mice via immunohistochemistry and immunofluorescence staining. These findings suggest that Lip-honokiol activated the Wnt/β-catenin pathway and accelerated the transfer from the telogen to anagen stage and finally promoted the hair growth.
摘要：
已发现从木兰属中分离的脂质体和厚朴酚具有抗血管生成作用，抗炎和抗肿瘤特性。然而,没有关于它在头发生长中的作用的报告。毛囊是终生循环的细胞器，从生长期经过，capagen和telogen阶段，并由不同的信号通路调节，包括Wnt/β-catenin，缺口,表皮生长因子（EGF）和SonicHegehog（SHH）。Wnt信号对于毛囊胎盘发育的启动和脱发治疗的新潜在靶标至关重要。本研究旨在研究脂质体和厚朴酚（Lip-和厚朴酚）对诱导毛发生长的影响。我们鉴定了通过每日腹部注射脂质体和厚朴酚(Lip-和厚朴酚)处理后,在C57BL/6N小鼠的剃须区域中的毛发提前长大。我们首先证明了Lip-和厚朴酚通过免疫组织化学和免疫荧光染色激活了Wnt3a/β-catenin途径并下调了转化生长因子-β1（TGF-β1）以促进小鼠的毛发生长。这些发现表明，和厚朴酚激活了Wnt/β-catenin途径，并加速了从静止期到生长期的转移，最终促进了头发的生长。
