PDF(Pubmed)
Abstract：
Coronavirus infections have been a part of the animal kingdom for millennia. The difference emerging in the twenty-first century is that a greater number of novel coronaviruses are being discovered primarily due to more advanced technology and that a greater number can be transmitted to humans, either directly or via an intermediate host. This has a range of effects from annual infections that are mild to full-blown pandemics. This review compares the zoonotic potential and relationship between MERS, SARS-CoV, and SARS-CoV-2. The role of bats as possible host species and possible intermediate hosts including pangolins, civets, mink, birds, and other mammals are discussed with reference to mutations of the viral genome affecting zoonosis. Ecological, social, cultural, and environmental factors that may play a role in zoonotic transmission are considered with reference to SARS-CoV, MERS, and SARS-CoV-2 and possible future zoonotic events.
摘要：
几千年来，冠状病毒感染一直是动物界的一部分。二十一世纪出现的区别在于，主要由于更先进的技术而发现了更多的新型冠状病毒，并且可以将更多的病毒传播给人类，直接或通过中间主机。这具有一系列影响，从年度感染到轻度大流行。这篇综述比较了MERS之间的人畜共患潜力和关系，SARS-CoV,和SARS-CoV-2.蝙蝠作为可能的宿主物种和可能的中间宿主，包括穿山甲，Civets,水貂,鸟,和其他哺乳动物的讨论参考影响人畜共患病的病毒基因组的突变。生态,社会,文化,以及可能在人畜共患传播中起作用的环境因素，参考SARS-CoV，MERS,SARS-CoV-2和未来可能的人畜共患事件。
