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Abstract：
The main objective of this review was to describe and quantify the association between Fusobacterium necrophorum (FN) and acute sore throat in primary healthcare (PHC).
In this systematic review and meta-analysis, we searched Scopus and PubMed for case-control studies reporting the prevalence of FN in patients attending primary care for an uncomplicated acute sore throat as well as in healthy controls. Only studies published in English were considered. Publications were not included if they were case studies, or if they included patients prescribed antibiotics before the throat swab, patients with a concurrent malignant disease, on immunosuppression, having an HIV infection, or patients having another acute infection in addition to a sore throat. Inclusion criteria and methods were specified in advance and published in PROSPERO. The primary outcome was positive etiologic predictive value (P-EPV), quantifying the probability for an association between acute sore throat and findings of FN in the pharynx. For comparison, our secondary outcome was the corresponding P-EPV for group A Streptococcus (GAS).
PubMed and Scopus yielded 258 and 232 studies, respectively. Removing duplicates and screening the abstracts resulted in 53 studies subsequently read in full text. For the four studies of medium to high quality included in the meta-analysis, the cumulative P-EPV regarding FN was 64% (95% CI 33% to 83%). GAS, based on data from the same publications and patients, yielded a positive EPV of 93% (95% CI 83% to 99%).
The results indicate that FN may play a role in PHC patients with an acute sore throat, but the association is much weaker compared with GAS.
In this systematic review and meta-analysis, we searched Scopus and PubMed for case-control studies reporting the prevalence of FN in patients attending primary care for an uncomplicated acute sore throat as well as in healthy controls. Only studies published in English were considered. Publications were not included if they were case studies, or if they included patients prescribed antibiotics before the throat swab, patients with a concurrent malignant disease, on immunosuppression, having an HIV infection, or patients having another acute infection in addition to a sore throat. Inclusion criteria and methods were specified in advance and published in PROSPERO. The primary outcome was positive etiologic predictive value (P-EPV), quantifying the probability for an association between acute sore throat and findings of FN in the pharynx. For comparison, our secondary outcome was the corresponding P-EPV for group A Streptococcus (GAS).
PubMed and Scopus yielded 258 and 232 studies, respectively. Removing duplicates and screening the abstracts resulted in 53 studies subsequently read in full text. For the four studies of medium to high quality included in the meta-analysis, the cumulative P-EPV regarding FN was 64% (95% CI 33% to 83%). GAS, based on data from the same publications and patients, yielded a positive EPV of 93% (95% CI 83% to 99%).
The results indicate that FN may play a role in PHC patients with an acute sore throat, but the association is much weaker compared with GAS.
摘要：
这篇综述的主要目的是描述和量化坏死梭杆菌（FN）与初级医疗保健（PHC）中急性咽喉痛之间的关联。
在这篇系统综述和荟萃分析中，我们搜索了Scopus和PubMed的病例对照研究,这些研究报告了在无并发症急性咽喉痛的初级保健患者以及健康对照组中FN的患病率.仅考虑以英文发表的研究。如果是案例研究，则不包括出版物，或者如果他们包括病人在咽拭子前开了抗生素，患有并发恶性疾病的患者，关于免疫抑制，患有艾滋病毒感染，或除喉咙痛外还有其他急性感染的患者。纳入标准和方法已提前指定，并在PROSPERO中发布。主要结果是阳性病因预测值（P-EPV），量化急性咽喉痛与咽部FN发现之间关联的概率。为了比较，我们的次要结局是A组链球菌(GAS)的相应P-EPV.
PubMed和Scopus进行了258和232项研究，分别。删除重复项并筛选摘要导致53项研究随后全文阅读。对于荟萃分析中包含的四项中高质量研究，FN的累积P-EPV为64%(95%CI33%~83%).GAS,基于来自相同出版物和患者的数据，阳性EPV为93%（95%CI83%至99%）。
结果表明，FN可能在PHC急性喉咙痛患者中发挥作用，但与GAS相比，这种关联要弱得多。
在这篇系统综述和荟萃分析中，我们搜索了Scopus和PubMed的病例对照研究,这些研究报告了在无并发症急性咽喉痛的初级保健患者以及健康对照组中FN的患病率.仅考虑以英文发表的研究。如果是案例研究，则不包括出版物，或者如果他们包括病人在咽拭子前开了抗生素，患有并发恶性疾病的患者，关于免疫抑制，患有艾滋病毒感染，或除喉咙痛外还有其他急性感染的患者。纳入标准和方法已提前指定，并在PROSPERO中发布。主要结果是阳性病因预测值（P-EPV），量化急性咽喉痛与咽部FN发现之间关联的概率。为了比较，我们的次要结局是A组链球菌(GAS)的相应P-EPV.
PubMed和Scopus进行了258和232项研究，分别。删除重复项并筛选摘要导致53项研究随后全文阅读。对于荟萃分析中包含的四项中高质量研究，FN的累积P-EPV为64%(95%CI33%~83%).GAS,基于来自相同出版物和患者的数据，阳性EPV为93%（95%CI83%至99%）。
结果表明，FN可能在PHC急性喉咙痛患者中发挥作用，但与GAS相比，这种关联要弱得多。
