PDF(Pubmed)
Abstract：
UNASSIGNED: The treatment of vitiligo is often challenging and requires a multi-modality approach. Fractional carbon dioxide (FCO2) laser has been studied as an adjuvant therapy in cases of vitiligo. Autologous platelet-rich plasma (PRP) is rich in growth factors, which may contribute to the growth of melanocytes, and thus help in the repigmentation of vitiligo patches. We aimed to study the combination of these two modalities for the treatment of vitiligo.
UNASSIGNED: The aim of this study was to compare the efficacy and safety of FCO2 laser with PRP and FCO2 laser alone as an adjuvant therapy in stable non-segmental vitiligo (NSV) patients.
UNASSIGNED: A prospective, randomized, comparative, open-label interventional study was carried out for a period of 18 months from December 2017 to June 2019, at a tertiary care hospital.
UNASSIGNED: Seventy patients with stable, NSV were assessed for eligibility; 66 patients were randomized equally into two groups. Group A received treatment with FCO2 laser with intralesional PRP, whereas Group B was treated with FCO2 laser alone. Patients in both the groups were treated with one therapy session and were followed up monthly for a period of 3 months. All the patients received topical psoralen with ultraviolet A (UVA) PUVA-sol treatment. Baseline and monthly assessments were done by VITILIGO AREA SEVERITY INDEX and standardized photographs.
UNASSIGNED: VASI score reduction was significantly more in the Group A with (mean ± standard deviation [SD]) 9.5 ± 0.22, 5.8 ± 1.12, and 3.6 ± 1.81 as compared to Group B 11.9 ± 2.83, 9.9 ± 3.11, and 8.9 ± 3.46 at each subsequent follow-up visits, respectively. Side effects such as burning sensation, erythema, and crusting were seen less frequently and lasted for a short period in Group A in comparison to those in Group B.
UNASSIGNED: Combination of FCO2 laser and autologous intralesional PRP has a synergetic effect in treating patients with vitiligo as an adjuvant therapy with minimal adverse effects.
UNASSIGNED: The aim of this study was to compare the efficacy and safety of FCO2 laser with PRP and FCO2 laser alone as an adjuvant therapy in stable non-segmental vitiligo (NSV) patients.
UNASSIGNED: A prospective, randomized, comparative, open-label interventional study was carried out for a period of 18 months from December 2017 to June 2019, at a tertiary care hospital.
UNASSIGNED: Seventy patients with stable, NSV were assessed for eligibility; 66 patients were randomized equally into two groups. Group A received treatment with FCO2 laser with intralesional PRP, whereas Group B was treated with FCO2 laser alone. Patients in both the groups were treated with one therapy session and were followed up monthly for a period of 3 months. All the patients received topical psoralen with ultraviolet A (UVA) PUVA-sol treatment. Baseline and monthly assessments were done by VITILIGO AREA SEVERITY INDEX and standardized photographs.
UNASSIGNED: VASI score reduction was significantly more in the Group A with (mean ± standard deviation [SD]) 9.5 ± 0.22, 5.8 ± 1.12, and 3.6 ± 1.81 as compared to Group B 11.9 ± 2.83, 9.9 ± 3.11, and 8.9 ± 3.46 at each subsequent follow-up visits, respectively. Side effects such as burning sensation, erythema, and crusting were seen less frequently and lasted for a short period in Group A in comparison to those in Group B.
UNASSIGNED: Combination of FCO2 laser and autologous intralesional PRP has a synergetic effect in treating patients with vitiligo as an adjuvant therapy with minimal adverse effects.
摘要：
■白癜风的治疗通常具有挑战性，需要多模态方法。已经研究了分数二氧化碳（FCO2）激光作为白癜风病例的辅助治疗。自体富血小板血浆(PRP)富含生长因子,这可能有助于黑素细胞的生长，从而帮助白癜风斑块的色素沉着。我们旨在研究这两种方法的结合治疗白癜风。
■这项研究的目的是比较FCO2激光与PRP和FCO2激光单独作为稳定的非节段白癜风（NSV）患者的辅助治疗的疗效和安全性。
■预期，随机化，比较,自2017年12月至2019年6月,开放标签介入研究在三级医院进行,为期18个月.
■70例患者，评估NSV的合格性；将66例患者随机分为两组。A组接受FCO2激光与病灶内PRP治疗，而B组单独用FCO2激光治疗。两组患者均接受一次治疗，每月随访3个月。所有患者均接受补骨脂素与紫外线A（UVA）PUVA-sol治疗。通过VITILIGO区域严重指数和标准化照片进行基线和每月评估。
■在随后的每次随访中，与B组11.9±2.83、9.9±3.11和8.9±3.46相比，A组的VASI评分降低更明显，（平均值±标准差[SD]）9.5±0.22、5.8±1.12和3.6±1.81，分别。副作用如灼烧感，红斑,与B组相比，A组结痂的频率较低，持续时间较短。
■FCO2激光和自体病灶内PRP联合治疗白癜风患者具有协同作用，作为辅助治疗，副作用最小。
■这项研究的目的是比较FCO2激光与PRP和FCO2激光单独作为稳定的非节段白癜风（NSV）患者的辅助治疗的疗效和安全性。
■预期，随机化，比较,自2017年12月至2019年6月,开放标签介入研究在三级医院进行,为期18个月.
■70例患者，评估NSV的合格性；将66例患者随机分为两组。A组接受FCO2激光与病灶内PRP治疗，而B组单独用FCO2激光治疗。两组患者均接受一次治疗，每月随访3个月。所有患者均接受补骨脂素与紫外线A（UVA）PUVA-sol治疗。通过VITILIGO区域严重指数和标准化照片进行基线和每月评估。
■在随后的每次随访中，与B组11.9±2.83、9.9±3.11和8.9±3.46相比，A组的VASI评分降低更明显，（平均值±标准差[SD]）9.5±0.22、5.8±1.12和3.6±1.81，分别。副作用如灼烧感，红斑,与B组相比，A组结痂的频率较低，持续时间较短。
■FCO2激光和自体病灶内PRP联合治疗白癜风患者具有协同作用，作为辅助治疗，副作用最小。
