UNASSIGNED: The aim of this study was to compare the efficacy and safety of FCO2 laser with PRP and FCO2 laser alone as an adjuvant therapy in stable non-segmental vitiligo (NSV) patients.
UNASSIGNED: A prospective, randomized, comparative, open-label interventional study was carried out for a period of 18 months from December 2017 to June 2019, at a tertiary care hospital.
UNASSIGNED: Seventy patients with stable, NSV were assessed for eligibility; 66 patients were randomized equally into two groups. Group A received treatment with FCO2 laser with intralesional PRP, whereas Group B was treated with FCO2 laser alone. Patients in both the groups were treated with one therapy session and were followed up monthly for a period of 3 months. All the patients received topical psoralen with ultraviolet A (UVA) PUVA-sol treatment. Baseline and monthly assessments were done by VITILIGO AREA SEVERITY INDEX and standardized photographs.
UNASSIGNED: VASI score reduction was significantly more in the Group A with (mean ± standard deviation [SD]) 9.5 ± 0.22, 5.8 ± 1.12, and 3.6 ± 1.81 as compared to Group B 11.9 ± 2.83, 9.9 ± 3.11, and 8.9 ± 3.46 at each subsequent follow-up visits, respectively. Side effects such as burning sensation, erythema, and crusting were seen less frequently and lasted for a short period in Group A in comparison to those in Group B.
UNASSIGNED: Combination of FCO2 laser and autologous intralesional PRP has a synergetic effect in treating patients with vitiligo as an adjuvant therapy with minimal adverse effects.
■这项研究的目的是比较FCO2激光与PRP和FCO2激光单独作为稳定的非节段白癜风(NSV)患者的辅助治疗的疗效和安全性。
■预期,随机化,比较,自2017年12月至2019年6月,开放标签介入研究在三级医院进行,为期18个月.
■70例患者,评估NSV的合格性;将66例患者随机分为两组。A组接受FCO2激光与病灶内PRP治疗,而B组单独用FCO2激光治疗。两组患者均接受一次治疗,每月随访3个月。所有患者均接受补骨脂素与紫外线A(UVA)PUVA-sol治疗。通过VITILIGO区域严重指数和标准化照片进行基线和每月评估。
■在随后的每次随访中,与B组11.9±2.83、9.9±3.11和8.9±3.46相比,A组的VASI评分降低更明显,(平均值±标准差[SD])9.5±0.22、5.8±1.12和3.6±1.81,分别。副作用如灼烧感,红斑,与B组相比,A组结痂的频率较低,持续时间较短。
■FCO2激光和自体病灶内PRP联合治疗白癜风患者具有协同作用,作为辅助治疗,副作用最小。