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Abstract：
BACKGROUND: Mycophenolate mofetil (MMF) is currently used in a wide spectrum of autoimmune diseases and has been rendered very effective in the management of systemic lupus erythematosus and lupus nephritis. MMF is known to be teratogenic (FDA category D) and therefore, women in childbearing period receiving MMF should be counselled to use effective contraceptive methods to avoid an unplanned pregnancy.
METHODS: A 22-year-old lady accidentally discovered to be pregnant while using MMF as a treatment of lupus nephritis which was replaced later on by azathioprine. After maternal and fetal evaluation, maternal lupus flare was confirmed and multiple fetal skeletal deformities associated with intrauterine growth restriction (IUGR) were diagnosed by 4-dimensional ultrasound. Termination of pregnancy was decided after shared decision making.
CONCLUSIONS: Women in childbearing period should be advised to postpone pregnancy for at least six weeks after stoppage of MMF therapy because of its potential teratogenic effects during pregnancy.
METHODS: A 22-year-old lady accidentally discovered to be pregnant while using MMF as a treatment of lupus nephritis which was replaced later on by azathioprine. After maternal and fetal evaluation, maternal lupus flare was confirmed and multiple fetal skeletal deformities associated with intrauterine growth restriction (IUGR) were diagnosed by 4-dimensional ultrasound. Termination of pregnancy was decided after shared decision making.
CONCLUSIONS: Women in childbearing period should be advised to postpone pregnancy for at least six weeks after stoppage of MMF therapy because of its potential teratogenic effects during pregnancy.
摘要：
背景：霉酚酸酯（MMF）目前用于广泛的自身免疫性疾病，并且在治疗系统性红斑狼疮和狼疮性肾炎中非常有效。已知MMF是致畸的(FDAD类)，因此，育龄期接受MMF的妇女应被建议使用有效的避孕方法,以避免意外怀孕.
方法：一位22岁的女士在使用MMF治疗狼疮性肾炎时意外发现怀孕，后来被硫唑嘌呤取代。经过母体和胎儿的评估，通过4维超声证实了母体狼疮发作,并诊断出与宫内生长受限(IUGR)相关的多个胎儿骨骼畸形.终止妊娠是在共同决策后决定的。
结论：育龄妇女应建议在停止MMF治疗后至少推迟6周妊娠，因为其在怀孕期间具有潜在的致畸作用。
方法：一位22岁的女士在使用MMF治疗狼疮性肾炎时意外发现怀孕，后来被硫唑嘌呤取代。经过母体和胎儿的评估，通过4维超声证实了母体狼疮发作,并诊断出与宫内生长受限(IUGR)相关的多个胎儿骨骼畸形.终止妊娠是在共同决策后决定的。
结论：育龄妇女应建议在停止MMF治疗后至少推迟6周妊娠，因为其在怀孕期间具有潜在的致畸作用。
