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Abstract：
BACKGROUND: Coagulopathy is the major cause of mortality and morbidity throughout the world. Globally, about 26-45% of healthy people have a history of bleeding symptoms, which may be a result of thrombocytopenia, factor deficiency, or pathological inhibitory.
OBJECTIVE: To assess coagulopathy and its associated factors among patients with bleeding diathesis at the University of Gondar Specialized Referral Hospital from January to May 2020.
METHODS: A cross-sectional study was conducted on 384 study participants with bleeding diathesis recruited by using a convenient sampling technique. Socio-demographic and clinical characteristics were collected by using questioners. Then 6 ml venous blood was collected with a needle and syringe method. About 3 ml blood was transferred to EDTA test tube for platelet count and 2.7 ml blood was transferred to a test tube containing 0.3 ml of 3.2% sodium citrated anticoagulant for coagulation test. For those study participants with prolonged coagulation tests, a mixing test was done. Blood film and stool examination were also done for malaria and intestinal parasite identification, respectively. The data were entered into EPI-Info version 3.5.3 and then transferred to SPSS version-20 for analysis. Descriptive statistics were summarized as percentages, means, and standard deviations. Bivariate and multivariate logistic regression was used to identify the associated factors, and a P-value less than 0.05 was considered statistically significant.
RESULTS: In this study, the prevalence of coagulopathy was 253/384 (65.9%; 95% CI: 61.16, 70.64). From them, 21.3% (54/253), 51.4% (130/253), and 27.3% (69/253) had only thrombocytopenia, only prolonged coagulation test, and mixed abnormality, respectively. Among participants with prolonged coagulation time, the prevalence of factor deficiency was 21.1% (42/199). Cardiac disease (AOR = 4.80; 95% CI: 2.65, 23.1), and other chronic diseases (AOR = 8.1; 95% CI: 1.84, 35.58) were significantly associated with coagulopathy.
CONCLUSIONS: In this study, coagulopathy due to inhibitory was a public health problem. The participants with cardiac and other chronic diseases were at high risk for coagulopathy. Therefore, mixing tests could be done for all prolonged coagulation tests and it could be considered as a routine laboratory test.
OBJECTIVE: To assess coagulopathy and its associated factors among patients with bleeding diathesis at the University of Gondar Specialized Referral Hospital from January to May 2020.
METHODS: A cross-sectional study was conducted on 384 study participants with bleeding diathesis recruited by using a convenient sampling technique. Socio-demographic and clinical characteristics were collected by using questioners. Then 6 ml venous blood was collected with a needle and syringe method. About 3 ml blood was transferred to EDTA test tube for platelet count and 2.7 ml blood was transferred to a test tube containing 0.3 ml of 3.2% sodium citrated anticoagulant for coagulation test. For those study participants with prolonged coagulation tests, a mixing test was done. Blood film and stool examination were also done for malaria and intestinal parasite identification, respectively. The data were entered into EPI-Info version 3.5.3 and then transferred to SPSS version-20 for analysis. Descriptive statistics were summarized as percentages, means, and standard deviations. Bivariate and multivariate logistic regression was used to identify the associated factors, and a P-value less than 0.05 was considered statistically significant.
RESULTS: In this study, the prevalence of coagulopathy was 253/384 (65.9%; 95% CI: 61.16, 70.64). From them, 21.3% (54/253), 51.4% (130/253), and 27.3% (69/253) had only thrombocytopenia, only prolonged coagulation test, and mixed abnormality, respectively. Among participants with prolonged coagulation time, the prevalence of factor deficiency was 21.1% (42/199). Cardiac disease (AOR = 4.80; 95% CI: 2.65, 23.1), and other chronic diseases (AOR = 8.1; 95% CI: 1.84, 35.58) were significantly associated with coagulopathy.
CONCLUSIONS: In this study, coagulopathy due to inhibitory was a public health problem. The participants with cardiac and other chronic diseases were at high risk for coagulopathy. Therefore, mixing tests could be done for all prolonged coagulation tests and it could be considered as a routine laboratory test.
摘要：
背景：凝血病是全世界死亡率和发病率的主要原因。全球范围内,大约26-45%的健康人有出血症状史，这可能是血小板减少症的结果，因子缺乏，或病理抑制。
目的：评估2020年1月至5月在冈达尔大学专业转诊医院就诊的出血素质患者的凝血功能障碍及其相关因素。
方法：对384名具有出血素质的研究参与者进行了横断面研究。通过使用提问者收集社会人口统计学和临床特征。然后用针头和注射器方法收集6ml静脉血。将约3ml血液转移到EDTA试管中进行血小板计数,将2.7ml血液转移到含有0.3ml3.2%柠檬酸钠抗凝剂的试管中进行凝血试验。对于那些长时间进行凝血测试的研究参与者，进行了混合试验。还进行了血膜和粪便检查，以鉴定疟疾和肠道寄生虫，分别。将数据输入EPI-Info版本3.5.3，然后转移到SPSS版本20进行分析。描述性统计数据总结为百分比，means,和标准偏差。双变量和多变量逻辑回归用于确定相关因素，P值小于0.05被认为具有统计学意义。
结果：在这项研究中，凝血功能障碍的患病率为253/384(65.9%;95%CI:61.16,70.64).从他们那里,21.3%（54/253），51.4%（130/253），和27.3%（69/253）只有血小板减少症，只有长时间的凝血试验，和混合异常，分别。在凝血时间延长的参与者中，因子缺乏的患病率为21.1%(42/199).心脏病（AOR=4.80；95%CI：2.65，23.1），和其他慢性疾病（AOR=8.1；95％CI：1.84，35.58）与凝血功能障碍显着相关。
结论：在这项研究中，由于抑制引起的凝血病是一个公共卫生问题。患有心脏病和其他慢性疾病的参与者有凝血病的高风险。因此,所有长时间的凝血试验都可以进行混合试验，可以将其视为常规实验室试验。
目的：评估2020年1月至5月在冈达尔大学专业转诊医院就诊的出血素质患者的凝血功能障碍及其相关因素。
方法：对384名具有出血素质的研究参与者进行了横断面研究。通过使用提问者收集社会人口统计学和临床特征。然后用针头和注射器方法收集6ml静脉血。将约3ml血液转移到EDTA试管中进行血小板计数,将2.7ml血液转移到含有0.3ml3.2%柠檬酸钠抗凝剂的试管中进行凝血试验。对于那些长时间进行凝血测试的研究参与者，进行了混合试验。还进行了血膜和粪便检查，以鉴定疟疾和肠道寄生虫，分别。将数据输入EPI-Info版本3.5.3，然后转移到SPSS版本20进行分析。描述性统计数据总结为百分比，means,和标准偏差。双变量和多变量逻辑回归用于确定相关因素，P值小于0.05被认为具有统计学意义。
结果：在这项研究中，凝血功能障碍的患病率为253/384(65.9%;95%CI:61.16,70.64).从他们那里,21.3%（54/253），51.4%（130/253），和27.3%（69/253）只有血小板减少症，只有长时间的凝血试验，和混合异常，分别。在凝血时间延长的参与者中，因子缺乏的患病率为21.1%(42/199).心脏病（AOR=4.80；95%CI：2.65，23.1），和其他慢性疾病（AOR=8.1；95％CI：1.84，35.58）与凝血功能障碍显着相关。
结论：在这项研究中，由于抑制引起的凝血病是一个公共卫生问题。患有心脏病和其他慢性疾病的参与者有凝血病的高风险。因此,所有长时间的凝血试验都可以进行混合试验，可以将其视为常规实验室试验。
