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Abstract：
Circulating lipoproteins as risk factors or prognostic indicators for various cancers have been investigated previously; however, no clear consensus has been reached. In this study, we aimed at evaluating the impact of serum lipoproteins on the prognosis of patients with squamous cell carcinoma of the head and neck (SCCHN). Levels of total cholesterol, low-density lipoproteins (LDL), high-density lipoproteins (HDL), triglycerides and lipoprotein(a) were measured in serum samples from 106 patients and 28 healthy controls. We found that HDL was the only lipoprotein exhibiting a significant difference in concentration between healthy controls and patients (p = 0.012). Kaplan-Meier survival curves indicated that patients with high levels of total cholesterol or LDL had better overall survival than patients with normal levels (p = 0.028 and p = 0.007, respectively). Looking at patients without lipid medication (n = 89) and adjusting for the effects of TNM stage and weight change, multivariate Cox regression models indicated that LDL was an independent prognostic factor for both overall (p = 0.005) and disease-free survival (p = 0.013). In summary, our study revealed that high LDL level is beneficial for survival outcome in patients with SCCHN. Use of cholesterol-lowering medicines for prevention or management of SCCHN needs to be evaluated carefully.
摘要：
先前已经研究了循环脂蛋白作为各种癌症的危险因素或预后指标；然而，尚未达成明确共识。在这项研究中,我们旨在评估血清脂蛋白对头颈部鳞状细胞癌(SCCHN)患者预后的影响.总胆固醇水平,低密度脂蛋白（LDL），高密度脂蛋白（HDL），在106名患者和28名健康对照者的血清样本中测量了甘油三酯和脂蛋白(a)。我们发现HDL是唯一在健康对照和患者之间表现出显着浓度差异的脂蛋白（p=0.012）。Kaplan-Meier存活曲线表明，总胆固醇或LDL水平高的患者比正常水平的患者具有更好的总生存期（分别为p=0.028和p=0.007）。观察没有脂质药物治疗的患者（n=89），并调整TNM分期和体重变化的影响，多变量Cox回归模型表明LDL是总体生存（p=0.005）和无病生存（p=0.013）的独立预后因素。总之,我们的研究显示,高LDL水平有利于SCCHN患者的生存结局.使用降胆固醇药物预防或管理SCCHN需要仔细评估。
