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Abstract：
Multidrug-resistant organism infections have become important in recent years due to the increased prevalence of diabetic foot ulcers and their possible consequences. This study aimed to systematically review and evaluate ulcer duration, healing time, hospital stay, amputation, and mortality rates in patients with diabetic foot ulcers caused by infection with multidrug-resistant organisms. PubMed, the Cochrane Library, and Web of Science were searched in May 2020 to find observational studies in English about the clinical outcomes of multidrug-resistant organism infection in diabetic foot ulcers. Eight studies met the inclusion criteria, and these studies included 923 patients. The overall methodological quality of the study was moderate. Ulcer duration was described in six studies, and there was no practical association with multidrug-resistant organisms. Two out of three studies reported a longer healing time in multidrug-resistant organism infections than in non-multidrug-resistant organism infections. Clinical outcomes included the duration of hospitalisation, surgeries, amputations, and deaths. Lower limb amputation was the most reported clinical outcome in the included studies, and was more prevalent in the multidrug-resistant organism infections. We concluded that there was not enough evidence that multidrug-resistant organisms hindered the healing of diabetic foot ulcers. In contrast to the clinical outcomes, multidrug-resistant organisms affect both amputation rates and mortality rates.
摘要：
近年来，由于糖尿病足溃疡的患病率及其可能的后果，多药耐药生物体感染已变得很重要。本研究旨在系统地回顾和评估溃疡的持续时间，愈合时间,住院,截肢,以及由多重耐药菌感染引起的糖尿病足溃疡患者的死亡率。PubMed,Cochrane图书馆,和WebofScience于2020年5月进行了搜索，以寻找有关糖尿病足溃疡多药耐药菌感染临床结局的英文观察性研究。八项研究符合纳入标准，这些研究包括923名患者。研究的总体方法学质量中等。六项研究描述了溃疡的持续时间，与多重耐药生物没有实际联系。三分之二的研究报告说，耐多药生物体感染的愈合时间比非耐多药生物体感染的愈合时间更长。临床结果包括住院时间，手术,截肢,和死亡。下肢截肢是纳入研究中报道最多的临床结果，并且在多重耐药生物体感染中更为普遍。我们得出的结论是，没有足够的证据表明多药耐药生物阻碍了糖尿病足溃疡的愈合。与临床结果相反，多重耐药生物影响截肢率和死亡率.
