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Abstract：
BACKGROUND: Estimates in the research literature on the health-related quality of life (QOL) associated with pneumococcal disease exhibit variation. It complicates the selection of estimates in modeling projects that evaluate the health impact and economic value of the prevention and treatment. This study reviewed the literature and developed pooled QOL estimates associated with pneumococcal disease states.
METHODS: We searched peer-reviewed literature for studies that reported pneumococcal disease-related QOL estimates. For each study, we extracted QOL estimates and categorized by age group and disease state. QOL estimates were converted to quality-adjusted life-years (QALYs). Pooled QALY estimates were calculated using simple average, sample-size weighting and inverse-variance weighting.
RESULTS: From 18 studies, we organized QOL estimates into 20 groups based on age and disease state. We observed the largest within-disease state variations of QALY estimates in meningitis-related disease states compared to other disease states. Across all age-disease state categories, the pooled QALY estimates ranged from 0.39 for meningitis with long-term sequelae among 0- to 18-year-olds, to 1.00 for non-inpatient pneumonia among 0- to 18-year-olds.
CONCLUSIONS: Our results indicated disparities in QOL estimates associated with pneumococcal disease from the literature. Pooled estimates provided a source of consistency that can be used in future modeling efforts.
METHODS: We searched peer-reviewed literature for studies that reported pneumococcal disease-related QOL estimates. For each study, we extracted QOL estimates and categorized by age group and disease state. QOL estimates were converted to quality-adjusted life-years (QALYs). Pooled QALY estimates were calculated using simple average, sample-size weighting and inverse-variance weighting.
RESULTS: From 18 studies, we organized QOL estimates into 20 groups based on age and disease state. We observed the largest within-disease state variations of QALY estimates in meningitis-related disease states compared to other disease states. Across all age-disease state categories, the pooled QALY estimates ranged from 0.39 for meningitis with long-term sequelae among 0- to 18-year-olds, to 1.00 for non-inpatient pneumonia among 0- to 18-year-olds.
CONCLUSIONS: Our results indicated disparities in QOL estimates associated with pneumococcal disease from the literature. Pooled estimates provided a source of consistency that can be used in future modeling efforts.
摘要：
背景：研究文献中对与肺炎球菌疾病相关的健康相关生活质量（QOL）的估计存在差异。在评估预防和治疗的健康影响和经济价值的建模项目中，它使估计的选择变得复杂。这项研究回顾了文献，并开发了与肺炎球菌疾病状态相关的汇总QOL估计。
方法：我们在同行评审的文献中检索了报告肺炎球菌疾病相关生活质量估计值的研究。对于每一项研究，我们提取了QOL估计值,并按年龄组和疾病状态进行分类.QOL估计值转换为质量调整寿命年(QALY)。汇总QALY估计值使用简单平均值计算，样本大小加权和方差逆加权。
结果：来自18项研究，我们根据年龄和疾病状态将QOL估计值分为20组.与其他疾病状态相比，我们观察到脑膜炎相关疾病状态中QALY估计值的最大疾病内状态变化。在所有年龄-疾病状态类别中，合并的QALY估计值范围为0至18岁有长期后遗症的脑膜炎的0.39，0至18岁的非住院性肺炎为1.00。
结论：我们的结果表明与肺炎球菌疾病相关的QOL估计值与文献存在差异。汇总估计提供了一致性的来源，可用于未来的建模工作。
方法：我们在同行评审的文献中检索了报告肺炎球菌疾病相关生活质量估计值的研究。对于每一项研究，我们提取了QOL估计值,并按年龄组和疾病状态进行分类.QOL估计值转换为质量调整寿命年(QALY)。汇总QALY估计值使用简单平均值计算，样本大小加权和方差逆加权。
结果：来自18项研究，我们根据年龄和疾病状态将QOL估计值分为20组.与其他疾病状态相比，我们观察到脑膜炎相关疾病状态中QALY估计值的最大疾病内状态变化。在所有年龄-疾病状态类别中，合并的QALY估计值范围为0至18岁有长期后遗症的脑膜炎的0.39，0至18岁的非住院性肺炎为1.00。
结论：我们的结果表明与肺炎球菌疾病相关的QOL估计值与文献存在差异。汇总估计提供了一致性的来源，可用于未来的建模工作。
