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Abstract：
Acrokeratosis paraneoplastica (Bazex syndrome) is a rare paraneoplastic dermatosis associated with internal malignancies. Clinical presentation is characterized by erythematous or violaceous scaly plaques involving the digits, nose, ears, palms, and soles. Nail changes commonly present concurrently with cutaneous manifestations. In this review, we characterize nail changes associated with acrokeratosis paraneoplastica. A total of 48 cases were analyzed. Nail findings were nonspecific, with the most common being nail plate thickening, onycholysis, subungual hyperkeratosis, longitudinal ridging, discoloration, and nail plate loss. In most patients, nail changes involved the majority of fingernails and toenails and most often appeared prior to the diagnosis of malignancy. The most common associated underlying malignancies were squamous cell carcinomas of the head and neck. A diagnosis of acrokeratosis paraneoplastica should be considered in patients with onychodystrophy involving multiple nails with accompanying atypical psoriasiform dermatoses. Screening for internal malignancies may significantly decrease morbidity and mortality for these patients.
摘要：
副角膜缘角化病（Bazex综合征）是一种与内部恶性肿瘤相关的罕见副肿瘤性皮肤病。临床表现以累及手指的红斑或紫罗兰色鳞片状斑块为特征，鼻子,耳朵,手掌,和鞋底。指甲变化通常与皮肤表现同时出现。在这次审查中,我们描述了与副肢端角化病相关的指甲变化。共48例进行分析。指甲发现是非特异性的，最常见的是指甲板增厚，甲状腺溶解症,甲下角化过度,纵向起皱,变色,和钉板损失。在大多数患者中，指甲的变化涉及大多数手指甲和脚趾甲，并且最常见于恶性肿瘤诊断之前。最常见的相关潜在恶性肿瘤是头颈部鳞状细胞癌。对于涉及多个指甲并伴有非典型牛皮癣样皮肤病的甲营养不良患者，应考虑诊断为癌旁角化病。筛查内部恶性肿瘤可以显着降低这些患者的发病率和死亡率。
