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Abstract：
Infectious bovine keratoconjunctivitis (IBK) involves multiple factors and opportunistic pathogens, including members of the genus Moraxella, specifically M bovis. The causal role of M bovis is clear, where the presence of virulence factors that facilitate colonization (pili) and host cytotoxicity (RTX toxins) are well characterized, and IBK has been reproduced in many models. Experimental infection with M bovoculi has failed to reproduce IBK-typical lesions in cattle thus far. However, recent work using genomics and mass spectrometry have found genomic diversity and recombination within these species, making species differentiation complex and challenging the ability to assign IBK causality to these organisms.
摘要：
牛传染性角膜结膜炎（IBK）涉及多种因素和机会性病原体，包括莫拉氏菌属的成员，特别是牛。牛M的因果作用是明确的，其中促进定植（菌毛）和宿主细胞毒性（RTX毒素）的毒力因子的存在得到了充分表征，IBK已经在许多型号中被复制。迄今为止，用Mbovoculi进行的实验性感染未能在牛中重现IBK典型的病变。然而,最近使用基因组学和质谱的工作发现了这些物种中的基因组多样性和重组，使物种分化变得复杂，并挑战将IBK因果关系分配给这些生物的能力。
