PDF(Pubmed)
Abstract：
OBJECTIVE: This study aimed to investigate the effect of ursodeoxycholic acid (UDCA) on the biodistribution and excretion of technetium-99m (Tc-99m)-labeled radiopharmaceuticals.
METHODS: Tc-99m hydroxy-methylene-diphosphonate (HDP), Tc-99m pertechnetate, and Tc-99m dimercaptosuccinic acid (DMSA) were injected via the tail vein of rats. After 30 min, the control group was administered saline, and the UDCA group was given UDCA orally. Scintigraphy images were acquired after 30 min and 1, 2, 3, and 4 h. Radioactivity and rate of change were compared. Tc-99m mercaptoacetyltriglycine (MAG₃) imaging was also performed.
RESULTS: In image analysis of Tc-99m HDP, radioactivity of the buttock was lower in the UDCA group at 4 h. Rates of change in the buttock were significantly different at 3 h-30 min and 4 h-30 min, and buttock radioactivity in the UDCA group had decreased more. In analysis of Tc-99m pertechnetate, radioactivity of the buttock was higher in the control group. Rates of change in the thyroid gland and buttock were different at 1 h-30 min, 3 h-30 min, and 4 h-30 min, with radioactivity in the UDCA group decreasing more. In the analysis of Tc-99m DMSA, while the radioactivity of the kidneys in the control group showed little decrease at 1 h-30 min, that in the UDCA group increased. In the analysis of Tc-99m MAG₃ images, radioactivity and radioactivity/total body radioactivity (TBA) values for the kidneys were higher in the UDCA group at 2 min. At 5 and 10 min, radioactivity/TBA values for soft tissue in the UDCA group were lower than those in the control group.
CONCLUSIONS: This study demonstrated that administration of UDCA increases renal excretion and soft tissue clearance of radiopharmaceuticals. This investigation could contribute to the broadening of applications of UDCA.
METHODS: Tc-99m hydroxy-methylene-diphosphonate (HDP), Tc-99m pertechnetate, and Tc-99m dimercaptosuccinic acid (DMSA) were injected via the tail vein of rats. After 30 min, the control group was administered saline, and the UDCA group was given UDCA orally. Scintigraphy images were acquired after 30 min and 1, 2, 3, and 4 h. Radioactivity and rate of change were compared. Tc-99m mercaptoacetyltriglycine (MAG₃) imaging was also performed.
RESULTS: In image analysis of Tc-99m HDP, radioactivity of the buttock was lower in the UDCA group at 4 h. Rates of change in the buttock were significantly different at 3 h-30 min and 4 h-30 min, and buttock radioactivity in the UDCA group had decreased more. In analysis of Tc-99m pertechnetate, radioactivity of the buttock was higher in the control group. Rates of change in the thyroid gland and buttock were different at 1 h-30 min, 3 h-30 min, and 4 h-30 min, with radioactivity in the UDCA group decreasing more. In the analysis of Tc-99m DMSA, while the radioactivity of the kidneys in the control group showed little decrease at 1 h-30 min, that in the UDCA group increased. In the analysis of Tc-99m MAG₃ images, radioactivity and radioactivity/total body radioactivity (TBA) values for the kidneys were higher in the UDCA group at 2 min. At 5 and 10 min, radioactivity/TBA values for soft tissue in the UDCA group were lower than those in the control group.
CONCLUSIONS: This study demonstrated that administration of UDCA increases renal excretion and soft tissue clearance of radiopharmaceuticals. This investigation could contribute to the broadening of applications of UDCA.
摘要：
目的：本研究旨在研究熊去氧胆酸（UDCA）对99m（Tc-99m）标记的放射性药物的生物分布和排泄的影响。
方法：Tc-99m羟基-亚甲基-二膦酸盐（HDP），Tc-99m高tech酸盐，通过大鼠的尾静脉注射Tc-99m二巯基琥珀酸（DMSA）。30分钟后,对照组给予生理盐水,UDCA组口服UDCA。在30分钟和1、2、3和4小时后采集闪烁图像。比较放射性和变化率。还进行了Tc-99m巯基乙酰三甘氨酸（MAG3）成像。
结果：在Tc-99mHDP的图像分析中，UDCA组在4h时臀部的放射性较低。在3h-30分钟和4h-30分钟时，臀部的变化率显着不同，UDCA组的臀部放射性下降更多。在Tc-99m高tech酸盐的分析中，对照组臀部放射性较高。1h-30min时甲状腺和臀部的变化率不同，3h-30min,和4小时-30分钟，UDCA组放射性下降更多。在对Tc-99mDMSA的分析中，而对照组肾脏的放射性在1小时-30分钟时几乎没有下降，在UDCA组中增加了。在对Tc-99mMAG图像的分析中，在2分钟时，UDCA组肾脏的放射性和放射性/全身放射性（TBA）值更高。在5和10分钟，UDCA组软组织放射性/TBA值均低于对照组。
结论：本研究证明UDCA的给药增加了放射性药物的肾排泄和软组织清除。这项研究可能有助于扩大UDCA的应用范围。
方法：Tc-99m羟基-亚甲基-二膦酸盐（HDP），Tc-99m高tech酸盐，通过大鼠的尾静脉注射Tc-99m二巯基琥珀酸（DMSA）。30分钟后,对照组给予生理盐水,UDCA组口服UDCA。在30分钟和1、2、3和4小时后采集闪烁图像。比较放射性和变化率。还进行了Tc-99m巯基乙酰三甘氨酸（MAG3）成像。
结果：在Tc-99mHDP的图像分析中，UDCA组在4h时臀部的放射性较低。在3h-30分钟和4h-30分钟时，臀部的变化率显着不同，UDCA组的臀部放射性下降更多。在Tc-99m高tech酸盐的分析中，对照组臀部放射性较高。1h-30min时甲状腺和臀部的变化率不同，3h-30min,和4小时-30分钟，UDCA组放射性下降更多。在对Tc-99mDMSA的分析中，而对照组肾脏的放射性在1小时-30分钟时几乎没有下降，在UDCA组中增加了。在对Tc-99mMAG
结论：本研究证明UDCA的给药增加了放射性药物的肾排泄和软组织清除。这项研究可能有助于扩大UDCA的应用范围。
